Bipolar disorder (BD) has been linked to abnormal frontal and striatal function, and elevated inflammatory responses. However, the impact of peripheral inflammation on the corticostriatal functional connectivity (FC) remains obscure in BD. The current study aimed to explore the association between peripheral inflammation and corticostriatal connectivity in euthymic BD. We recruited 25 euthymic BD patients and 43 healthy controls (HCs) from the community. Resting state functional images were obtained using 3T magnetic resonance imaging (fMRI), and striatal seed-based whole-brain functional connectivity analyses were performed, with the fasting plasma high-sensitivity C-reactive protein (hs-CRP) level entered as a regressor of interest. The participants also completed the Wisconsin Card-Sorting Test (WCST) and the Continuous Performance Test (CPT). The euthymic BD group had a similar hs-CRP level to the HC group, but a significantly poorer cognitive performance. Compared with the HC group, a higher connectivity between the right dorsal caudal putamen (dcP) and the ventral lateral prefrontal cortex (vlPFC) in the BD group was significantly correlated with a higher hs-CRP level. Stronger dcP-vlPFC connectivity was correlated with a lower CPT unmasked d' in the BD group. BD patients might be particularly sensitive to the effects of inflammation on corticostriatal connectivity. The potentially greater sensitivity of BD patients to peripheral inflammation may differentially modulate the cognitive and reward related corticostriatal circuitry, which may contribute to the pathophysiology of cognitive-affective dysregulation in the euthymic state. Anti-inflammatory or other circuit-specific treatment is warranted for individualized treatment in BD.

中文翻译：

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外周炎症与双相情感障碍患者的皮质纹状体回路功能障碍和执行功能障碍有关

双相情感障碍 (BD) 与异常的额叶和纹状体功能以及炎症反应升高有关。然而，外周炎症对皮质纹状体功能连接 (FC) 的影响在 BD 中仍然不清楚。目前的研究旨在探讨正常 BD 中外周炎症与皮质纹状体连接之间的关联。我们从社区招募了 25 名心境正常的 BD 患者和 43 名健康对照 (HC)。使用 3T 磁共振成像 (fMRI) 获得静息状态功能图像，并进行基于纹状体种子的全脑功能连接分析，空腹血浆高敏 C 反应蛋白 (hs-CRP) 水平作为回归因子输入出于兴趣。参与者还完成了威斯康星卡片分类测试 (WCST) 和连续性能测试 (CPT)。心境正常的 BD 组的 hs-CRP 水平与 HC 组相似，但认知能力明显较差。与 HC 组相比，BD 组右背尾壳核 (dcP) 和腹侧前额叶皮层 (vlPFC) 之间更高的连接性与更高的 hs-CRP 水平显着相关。更强的 dcP-vlPFC 连接与 BD 组中较低的 CPT unmasked d' 相关。BD 患者可能对炎症对皮质纹状体连接的影响特别敏感。BD 患者对外周炎症的潜在更大敏感性可能会不同地调节与认知和奖励相关的皮质纹状体回路，这可能有助于情绪正常状态下认知情感失调的病理生理学。