Glutamatergic dysregulation is known to contribute to obsessive-compulsive disorder (OCD). Astrocytic glutamate transporter 1 (GLT1) is responsible for the majority of glutamate clearance. However, the role of GLT1 in OCD-like behavior remains unclear. Here, we found that astrocytic GLT1 deficient mice showed increased wheel running activity but reduced home cage activity. Notably, they exhibited elevated grooming/rearing time and increased repetitive behavior counts in contextual and cued fear conditioning. In addition, they showed increased rearing counts in the metabolic chamber, and also augmented rearing time and jumping counts in the open field test. Taken together, our findings suggest that astrocytic GLT1 deficiency promotes OCD-like repetitive behaviors.

已知谷氨酸能失调会导致强迫症 (OCD)。星形胶质细胞谷氨酸转运蛋白 1 (GLT1) 负责大部分谷氨酸清除。然而，GLT1 在强迫症样行为中的作用仍不清楚。在这里，我们发现星形胶质细胞 GLT1 缺陷小鼠表现出轮跑活动增加，但笼子活动减少。值得注意的是，它们在情境和暗示的恐惧调节中表现出更长的梳理/饲养时间和重复行为计数。此外，它们在代谢室中表现出增加的饲养次数，并且在旷场测试中也增加了饲养时间和跳跃次数。综上所述，我们的研究结果表明，星形胶质细胞 GLT1 缺陷会促进类似强迫症的重复行为。