当前位置: X-MOL 学术Open Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine.
Open Biology ( IF 5.8 ) Pub Date : 2020-09-16 , DOI: 10.1098/rsob.200111
Mahmoud Mohammad Yaseen 1 , Nizar Mohammad Abuharfeil 1 , Homa Darmani 2 , Ammar Daoud 3
Affiliation  

Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status. In fact, the immune system is naturally equipped with immunoregulatory cells that can limit immune activation and inflammation. However, chronic activation of downregulatory immune responses is also associated with unwanted consequences that, in turn, could lead to disease progression as seen in the case of cancer and chronic infections. Myeloid-derived suppressor cells (MDSCs) are now considered to play a pivotal role in the pathogenesis of different inflammatory pathological conditions, including different types of cancer and chronic infections. As a potent immunosuppressor cell population, MDSCs can inhibit specific and non-specific immune responses via different mechanisms that, in turn, lead to disease persistence. One such mechanism by which MDSCs can activate their immunosuppressive effects is accomplished by secreting copious amounts of immunosuppressant molecules such as interleukin-10 (IL-10). In this article, we will focus on the pathological role of MDSC expansion in chronic inflammatory conditions including cancer, sepsis/infection, autoimmunity, asthma and ageing, as well as some of the mechanisms by which MDSCs/IL-10 contribute to the disease progression in such conditions.



中文翻译:

髓源性抑制细胞的免疫抑制机制:白细胞介素 10 作为关键免疫调节细胞因子的作用。

慢性免疫激活和炎症是许多病理状况的不良后果,因为它们可能导致组织损伤和免疫衰竭,这两者都会使病理状况恶化。事实上,免疫系统天然配备了免疫调节细胞,可以限制免疫激活和炎症。然而,下调免疫反应的慢性激活也与不良后果相关,这反过来又可能导致疾病进展,如癌症和慢性感染的情况。髓源性抑制细胞 (MDSCs) 现在被认为在不同炎症病理状况的发病机制中起关键作用,包括不同类型的癌症和慢性感染。作为有效的免疫抑制细胞群,MDSCs 可以通过不同的机制抑制特异性和非特异性免疫反应,进而导致疾病持续存在。MDSC 激活其免疫抑制作用的一种机制是通过分泌大量免疫抑制分子如白细胞介素 10 (IL-10) 来实现的。在本文中,我们将重点介绍 MDSC 扩增在慢性炎症(包括癌症、败血症/感染、自身免疫、哮喘和衰老)中的病理作用,以及 MDSC/IL-10 促进疾病进展的一些机制在这样的条件下。MDSC 激活其免疫抑制作用的一种机制是通过分泌大量免疫抑制分子如白细胞介素 10 (IL-10) 来实现的。在本文中,我们将重点介绍 MDSC 扩增在慢性炎症(包括癌症、败血症/感染、自身免疫、哮喘和衰老)中的病理作用,以及 MDSC/IL-10 促进疾病进展的一些机制在这样的条件下。MDSC 激活其免疫抑制作用的一种机制是通过分泌大量免疫抑制分子如白细胞介素 10 (IL-10) 来实现的。在本文中,我们将重点介绍 MDSC 扩增在慢性炎症(包括癌症、败血症/感染、自身免疫、哮喘和衰老)中的病理作用,以及 MDSC/IL-10 促进疾病进展的一些机制在这样的条件下。

更新日期:2020-09-16
down
wechat
bug