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Synthesis of (Trifluoromethyldiazirinyl)phenyl-boronic Acid Derivatives for Photoaffinity Labeling
Heterocycles ( IF 0.8 ) Pub Date : 2020-09-16 , DOI: 10.3987/com-20-s(k)23
Makoto Hashimoto , Manami Hashinoki , Natsumi Kurokawa , Yuta Murai , Zetryana Puteri Tachrim , Yasuko Sakihama , Takeyuki Suzuki

Trifluoromethylphenyldiazirine is one of the most reliable photophores for photoaffinity labeling during functional analysis of biologically active compounds. Phenylboronic acid derivatives containing trifluoromethyldiazirinyl moiety have not yet been reported. The construction of the photophore was achieved using (3-formylphenyl)boronic acid and (4-formylphenyl)boronic acid pinacol esters effectively.

中文翻译:

用于光亲和标记的(三氟甲基重氮基)苯基硼酸衍生物的合成

三氟甲基苯基重氮是生物活性化合物功能分析过程中用于光亲和标记的最可靠的荧光体之一。尚未报道含有三氟甲基二嗪啉基部分的苯硼酸衍生物。有效地使用(3-甲酰基苯基)硼酸和(4-甲酰基苯基)硼酸频哪醇酯实现了荧光团的构建。
更新日期:2020-09-16
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