The prevalence of potential risk factors for postoperative cough after thyroidectomy remain unknown. The current study aimed to research postoperative cough in patients undergoing thyroid surgery prospectively. Adult patients who underwent primary thyroid surgery were selected prospectively. Data regarding age, sex, BMI, pathology and surgical procedure were collected and analyzed. The Leicester Cugh Questionnaire (LCQ) was required to be completed by all patients before operation, 2 weeks and 4 weeks after operation. There were 1264 patients enrolled in total. Eleven patients with vocal cord paralysis were excluded. In patients with benign disease, postoperative cough occurred in 61 patients, with an prevalence rate of 17. 0% compared to an prevalence rate of 33.1% in patients with malignant disease; the difference was significant. For benign patients, the factors of smoking and operation time were independently related to the occurrence of postoperative cough. For malignant patients, the factors of smoking, operation time, operation extent, and the number of positive nodes at level 6 were independently related to the occurrence of postoperative cough. There was no significant difference regarding the LCQ score in patients with benign or malignant disease at the preoperative and the postoperative 4-week time periods. Patients with malignant disease had a significantly lower LCQ score than patients with benign disease at the postoperative 2-week time point (p = 0.004). Patients undergoing thyroid cancer surgery had a higher incidence of postoperative cough and were also associated with a decreased cough-related quality of life. The factors of smoking and operation time were the most important predictors for postoperative cough after thyroidectomy.

中文翻译：

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甲状腺切除术后短期咳嗽的发生率和危险因素。

甲状腺切除术后术后咳嗽的潜在危险因素的发生率仍然未知。目前的研究旨在前瞻性研究甲状腺手术患者的术后咳嗽情况。前瞻性选择接受甲状腺原发手术的成年患者。收集和分析有关年龄，性别，BMI，病理学和手术程序的数据。所有患者均需在手术前，手术后2周和4周完成莱斯特·库格问卷（LCQ）。共有1264名患者入组。排除11例声带麻痹患者。在良性疾病患者中，61例发生了术后咳嗽，患病率为17. 0％，而恶性疾病患者的患病率为33.1％；差异很大。对于良性患者，吸烟和手术时间的因素与术后咳嗽的发生独立相关。对于恶性患者，吸烟，手术时间，手术程度和6级阳性结节数目的因素与术后咳嗽的发生独立相关。在术前和术后4周时间段内，良性或恶性疾病患者的LCQ评分无显着差异。在术后2周的时间点，恶性疾病患者的LCQ评分明显低于良性疾病患者（p = 0.004）。进行甲状腺癌手术的患者术后咳嗽的发生率较高，并且与咳嗽相关的生活质量下降有关。