In the present study, polyurethane (PU) nanocomposite scaffolds containing bioactive glass nanoparticles (BG-NPs) were successfully fabricated through the electrospinning process. The BG-NPs were synthesized through the sol–gel method. PU solutions (10% w/v) containing different weight percentages of the BG-NPs (5, 10 and 15 wt.%) in dimethylformamide/tetrahydrofuran were prepared. To determine both the size of BG-NPs and the diameter of the nanofibers, transmission electron microscopy and scanning electron microscopy were carried out. The surface morphology, mechanical properties, bioactivity and degradation rate of the scaffolds were studied. Fourier transform infrared spectroscopy, X-ray diffraction and energy-dispersive X-ray spectroscopy confirmed the presence of BG within the scaffolds. The tensile strength of nanocomposite scaffolds was in the range 5–8 MPa, which is in good agreement with the tensile strength of cancellous bone tissue. MG63 cells attached to and proliferated well within the scaffolds; therefore, cellular growth was also improved in the nanocomposite scaffolds. Based on the results, the novel PU/BG-NP (10 wt.%) nanocomposite scaffold has a great potential to be applied in cancellous bone tissue engineering.

中文翻译：

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含有生物活性玻璃纳米粒子的新型电纺聚氨酯支架

在本研究中，通过电纺丝工艺成功地制备了具有生物活性玻璃纳米粒子（BG-NPs）的聚氨酯（PU）纳米复合材料支架。BG-NPs是通过溶胶-凝胶法合成的。制备在二甲基甲酰胺/四氢呋喃中含有不同重量百分比的BG-NP（5、10和15重量％）的PU溶液（10％w / v）。为了确定BG-NP的尺寸和纳米纤维的直径，进行了透射电子显微镜和扫描电子显微镜。研究了支架的表面形貌，力学性能，生物活性和降解速率。傅里叶变换红外光谱，X射线衍射和能量色散X射线光谱证实了支架中BG的存在。纳米复合材料支架的抗张强度为5-8 MPa，与松质骨组织的抗张强度非常吻合。MG63细胞附着于支架并在支架内良好增殖；因此，纳米复合支架的细胞生长也得到改善。根据结果​​，新型PU / BG-NP（10 wt。％）纳米复合支架具有巨大的潜力，可用于松质骨组织工程。