A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy,Journal of Materials Chemistry B

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A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-09-16 , DOI: 10.1039/d0tb01707h
Genhua Liu _{1,

2,

3,

4,

5} , Huining Liang _{1,

2,

3,

4,

5} , Ye He _{1,

2,

3,

4,

5} , Lu Lu _{1,

2,

3,

4,

5} , Lu Wang _{1,

2,

3,

4,

5} , Peng Liu _{1,

2,

3,

4,

5} , Kaiyong Cai _{1,

2,

3,

4,

5}

Affiliation

To enhance the efficacy of nanoparticle-based cancer therapy with reduced side effects and promote its clinical translation, a biocompatible nanocomposite based on mesoporous silica-coated gold nanorods (AuNR@MSN) for triple tumor therapy is reported in this study. The gold core served as a hyperthermia agent, while the MSN shell acted as a reservoir of chemotherapeutics owing to its excellent loading capacity. Cytochrome c with the apoptosis inducing function was anchored on the surface of AuNR@MSN to prevent drug leakage through redox-responsive disulfide bonds. The successful construction of a nanocomposite was confirmed by characterization of the physicochemical properties. In vitro and in vivo studies demonstrated that the nanocomposite displayed an optimizing anti-tumor effect with a synergistic strategy of excellent photothermal therapy, chemotherapy and protein therapy. Therefore, this cooperative strategy paves the way for high-efficiency oncotherapy with reduced side effects.

中文翻译：

基于介孔二氧化硅涂层的金纳米棒的纳米平台用于癌症三联疗法

为了提高具有减少副作用的基于纳米颗粒的癌症治疗的功效并促进其临床翻译，本研究报道了一种基于介孔二氧化硅涂层的金纳米棒（AuNR @ MSN）的生物相容性纳米复合材料，可用于三重肿瘤治疗。金芯用作热疗剂，而MSN壳由于其出色的负载能力而充当化学药品的储存库。具有凋亡诱导功能的细胞色素c被锚定在AuNR @ MSN的表面，以防止药物通过氧化还原反应性二硫键泄漏。通过理化性质的表征证实了纳米复合材料的成功构建。体外和体内研究表明，纳米复合材料具有出色的抗肿瘤作用，并具有出色的光热疗法，化学疗法和蛋白质疗法的协同策略。因此，这种合作策略为减少副作用的高效肿瘤治疗铺平了道路。

更新日期：2020-10-08

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