Rapidly accumulating literature has proven feasibility of the zebrafish xenograft models in cancer research. Nevertheless, online databases for searching the current zebrafish xenograft literature are in great demand. Herein, we have developed a manually curated database, called ZenoFishDb v1.1 (https://konulab.shinyapps.io/zenofishdb), based on R Shiny platform aiming to provide searchable information on ever increasing collection of zebrafish studies for cancer cell line transplantation and patient-derived xenografts (PDXs). ZenoFishDb v1.1 user interface contains four modules: DataTable, Visualization, PDX Details, and PDX Charts. The DataTable and Visualization pages represent xenograft study details, including injected cell lines, PDX injections, molecular modifications of cell lines, zebrafish strains, as well as technical aspects of the xenotransplantation procedures in table, bar, and/or pie chart formats. The PDX Details module provides comprehensive information on the patient details in table format and can be searched and visualized. Overall, ZenoFishDb v1.1 enables researchers to effectively search, list, and visualize different technical and biological attributes of zebrafish xenotransplantation studies particularly focusing on the new trends that make use of reporters, RNA interference, overexpression, or mutant gene constructs of transplanted cancer cells, stem cells, and PDXs, as well as distinguished host modifications.

中文翻译：

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ZenoFishDb v1.1：斑马鱼异种移植研究数据库。

迅速积累的文献证明了斑马鱼异种移植模型在癌症研究中的可行性。然而，对搜索当前斑马鱼异种移植文献的在线数据库的需求很大。在此，我们基于R Shiny平台开发了一个手动策展的数据库，称为ZenoFishDb v1.1（https://konulab.shinyapps.io/zenofishdb），旨在提供有关癌细胞系斑马鱼研究不断增加的集合的可搜索信息。移植和患者来源的异种移植（PDX）。ZenoFishDb v1.1用户界面包含四个模块：DataTable，Visualization，PDX Details和PDX Charts。该DataTabl e和可视化这些页面以表格，条形图和/或饼图格式表示异种移植研究的详细信息，包括注入的细胞系，PDX注入，细胞系的分子修饰，斑马鱼品系以及异种移植程序的技术方面。该PDX详细模块提供了以表格的形式对患者详细全面的信息，并可以搜索和可视化。总体而言，ZenoFishDb v1.1使研究人员能够有效地搜索，列出和可视化斑马鱼异种移植研究的不同技术和生物学特性，尤其着眼于利用报告基因，RNA干扰，过表达或移植癌细胞突变基因构建体的新趋势。 ，干细胞和PDX以及杰出的宿主修饰。