Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of skin and soft tissue infections and their recurrences. Although traditionally not considered for use against MRSA, cefazolin presents a possible option when administered using ultrasonic drug dispersion (UD2). This novel technique localizes delivery of drug into the subcutaneous tissue and achieves concentrations that exceed the minimum inhibitory concentrations (MICs) of most clinical MRSA isolates. The purpose of this study was to evaluate the impact of achievable cefazolin concentrations on the rate and extent of bactericidal activity using time-kill methodologies

中文翻译：

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组织可达到的浓度的头孢唑啉对耐甲氧西林金黄色葡萄球菌的体外杀菌活性

背景：耐甲氧西林金黄色葡萄球菌（MRSA）是皮肤和软组织感染及其复发的主要原因。尽管传统上不考虑用于对抗 MRSA，但当使用超声药物分散 (UD2) 给药时，头孢唑啉提供了一种可能的选择。这种新技术将药物递送到皮下组织并达到超过大多数临床 MRSA 分离株的最小抑制浓度 (MIC) 的浓度。本研究的目的是使用时间杀死方法评估可达到的头孢唑啉浓度对杀菌活性的速率和程度的影响