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Optically Controlled Living Micromotors for the Manipulation and Disruption of Biological Targets.
Nano Letters ( IF 9.6 ) Pub Date : 2020-09-16 , DOI: 10.1021/acs.nanolett.0c02501
Hongbao Xin 1 , Nan Zhao 1 , Yunuo Wang 2 , Xiaoting Zhao 1 , Ting Pan 1 , Yang Shi 1 , Baojun Li 1
Affiliation  

Bioinspired and biohybrid micromotors represent a revolution in microrobotic research and are playing an increasingly important role in biomedical applications. In particular, biological micromotors that are multifunctional and can perform complex tasks are in great demand. Here, we report living and multifunctional micromotors based on single cells (green microalgae: Chlamydomonas reinhardtii) that are controlled by optical force. The micromotor’s locomotion can be carefully controlled in a variety of biological media including cell culture medium, saliva, human serum, plasma, blood, and bone marrow fluid. It exhibits the capabilities to perform multiple tasks, in particular, indirect manipulation of biological targets and disruption of biological aggregates including in vitro blood clots. These micromotors can also act as elements in reconfigurable motor arrays where they efficiently work collaboratively and synchronously. This work provides new possibilities for many in vitro biomedical applications including target manipulation, cargo delivery and release, and biological aggregate removal.

中文翻译:

用于操纵和破坏生物靶标的光控活微电机。

受生物启发的生物混合微电机代表了微机器人研究领域的一场革命,并在生物医学应用中发挥着越来越重要的作用。尤其是,对多功能且能够执行复杂任务的生物微马达的需求很大。在这里,我们报道了基于单细胞的生活型和多功能微型电机(绿色微藻:衣藻))由视力控制。可以在多种生物介质(包括细胞培养基,唾液,人血清,血浆,血液和骨髓液)中小心控制微电机的运动。它具有执行多项任务的能力,尤其是间接控制生物靶标和破坏包括体外血凝块在内的生物聚集体。这些微型电动机还可以充当可重配置电动机阵列中的元素,在这些电动机中,它们可以高效地协同工作并同步工作。这项工作为许多体外生物医学应用提供了新的可能性,包括目标操纵,货物运输和释放以及生物集料的去除。
更新日期:2020-10-15
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