The pathophysiological mechanism underlying pregnancy complications such as congenital malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known. However, the negative impact of the mother’s body oxidative imbalance on the fetus and the course of gestation is increasingly discussed. This article is an integrative review of some original studies and review papers on the effects of oxidative stress on the adverse pregnancy outcomes mainly birth defects in fetuses. A systematic search for English language articles published from 2010 until 2020 was made, using MEDLINE data. Additionally, we analyzed the Cochrane and Scopus databases, discussions with experts, and a review of bibliography of articles from scientifically relevant and valuable sources. The main purposes are to assess the contribution of the existing literature of associations of oxidative stress on the etiology of the abovementioned conditions and to identify relevant information and outline existing knowledge. Furthermore, the authors aim to find any gaps in the research, thereby providing grounds for our own research. The key search terms were “oxidative stress in pregnancy,” “oxidative stress and congenital malformations,” and “oxidative stress and adverse pregnancy outcomes.” Studies have confirmed that oxidative stress has a significant impact on pregnancy and is involved in the pathomechanism of adverse pregnancy outcomes.

中文翻译：

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氧化应激与妊娠的关联

妊娠并发症（如先天畸形，流产，先兆子痫或胎儿生长受限）的病理生理机制尚不完全清楚。然而，越来越多地讨论了母亲体内氧化不平衡对胎儿和妊娠过程的负面影响。本文是对某些原始研究和综述论文的综合综述，其中涉及氧化应激对不良妊娠结局（主要是胎儿的出生缺陷）的影响。使用MEDLINE数据，系统搜索了从2010年到2020年发表的英语文章。此外，我们分析了Cochrane和Scopus数据库，与专家进行了讨论，并回顾了来自具有科学意义和宝贵价值的文献的书目。主要目的是评估现有氧化应激关联文献对上述疾病的病因的贡献，并确定相关信息并概述现有知识。此外，作者的目的是发现研究中的任何空白，从而为我们自己的研究提供依据。关键搜索词是“妊娠中的氧化应激”，“氧化性应激和先天性畸形”以及“氧化性应激和不良妊娠结局”。研究已经证实，氧化应激对妊娠有重大影响，并与不良妊娠结局的发病机理有关。作者的目的是发现研究中的任何空白，从而为我们自己的研究提供依据。关键搜索词是“妊娠中的氧化应激”，“氧化性应激和先天性畸形”以及“氧化性应激和不良妊娠结局”。研究已经证实，氧化应激对妊娠有重大影响，并与不良妊娠结局的发病机理有关。作者的目的是发现研究中的任何空白，从而为我们自己的研究提供依据。关键搜索词是“妊娠中的氧化应激”，“氧化性应激和先天性畸形”以及“氧化性应激和不良妊娠结局”。研究已经证实，氧化应激对妊娠有重大影响，并与不良妊娠结局的发病机理有关。