Background. CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation. Objective. The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD). Results. In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147 was increased in intestinal tissue of patients with active IBD compared to that in the control group. What is more, CD147 is involved in intestinal barrier function and intestinal inflammation, which was attributed to the fact that it has an influence on MCT4 expression, a regulator of intestinal barrier function and intestinal inflammation, in HT-29 and CaCO2 cells. Most importantly, serum level of CD147 content is higher in active IBD than that in inactive IBD or healthy control, which could be a biomarker of IBD. Conclusion. The data suggested that increased CD147 level could be a biomarker of IBD in children.

中文翻译：

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CD147在儿童炎症性肠病中的临床意义

背景。CD147/basigin (Bsg) 是一种跨膜糖蛋白，可激活基质金属蛋白酶并促进炎症。客观。本研究旨在探讨CD147在炎症性肠病（IBD）发病机制中的临床意义。结果. 除单核细胞外，临床分析显示IBD与对照组的白细胞、中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞和红细胞均无显着性差异。免疫组化分析显示，与对照组相比，活动性 IBD 患者肠道组织中 CD147 升高。更重要的是，CD147 参与肠道屏障功能和肠道炎症，这归因于它影响 HT-29 和 CaCO2 细胞中 MCT4 的表达，MC​​T4 是肠道屏障功能和肠道炎症的调节剂。最重要的是，活动性IBD的血清CD147含量高于非活动性IBD或健康对照组，这可能是IBD的生物标志物。结论. 数据表明，CD147 水平升高可能是儿童 IBD 的生物标志物。