Background: Cancer is one of the major causes of death worldwide and the third leading cause of death in Iran. One of the proteins that are considered having anticancer effects is the adiponectin hormone. Adiponectin leads to programmed cell death, prevents cell growth and proliferation, and increases the expression levels of BCL2. Aim: The aim of this study was to assay the expression of adiponectin receptors (AdipoR1 and AdipoR2) genes in gastric cancer patients. Materials and Methods: In this case-control study, 42 gastric cancer patients and 52 volunteers as healthy controls were enrolled. Total RNA was extracted. cDNA was synthesized by the reverse transcription method, and expression analysis was performed by real-time PCR. The serum level of adiponectin was also measured by ELISA. Results: The expression of both AdipoR1 and AdipoR2 was significantly higher than the control group (p = 0.02). Serum adiponectin was significantly lower in gastric cancer cases when compared with normal controls (p = 0.03). Conclusion: We found that expression level of AdipoR1 and AdipoR2 is strongly higher; however, the level of circulating adiponectin is lower in gastric cancer. Our study suggests that the expression of AdipoR1 and AdipoR2, besides the low level of adiponectin, may play an important role in the development and/or progression of gastric cancer.
Gastrointest Tumors

中文翻译：

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胃癌中AdipoR1和AdipoR2的表达及血清脂联素水平

背景：癌症是全球主要死因之一，也是伊朗第三大死因。被认为具有抗癌作用的蛋白质之一是脂联素激素。脂联素导致程序性细胞死亡，阻止细胞生长和增殖，并增加BCL2的表达水平。目的：本研究的目的是检测胃癌患者脂联素受体（ AdipoR1和AdipoR2 ）基因的表达情况。材料和方法：在这项病例对照研究中，42 名胃癌患者和 52 名志愿者作为健康对照被纳入研究。提取总RNA。通过逆转录法合成cDNA，通过实时PCR进行表达分析。还通过ELISA测量脂联素的血清水平。结果： AdipoR1和AdipoR2的表达均显着高于对照组（p =0.02）。与正常对照组相比，胃癌患者的血清脂联素显着降低（p = 0.03）。结论：我们发现AdipoR1和AdipoR2的表达水平强烈地更高；然而，胃癌的循环脂联素水平较低。我们的研究表明，除了低水平的脂联素外， AdipoR1和AdipoR2的表达可能在胃癌的发生和/或进展中起重要作用。
胃肠肿瘤