With the increasing threat of bacterial infection to human health, the development of different antimicrobial agents is essential. Therefore, based on the photothermal conversion properties of gold nanomaterials, the polyelectrolyte (PE)-coated gold nanorods (GNR@PE) and gold nanostars (GNS@PE) are designed and synthesized. Consequently, the chemo-photothermal synergistic antibacterial effect is achieved. GNR@PE effectively eliminates the high toxicity of cetyltrimethylammonium bromide (CTAB), and both GNR@PE and GNS@PE have good biocompatibility and stability. Because of the cation coating, GNR@PE and GNS@PE show high localized surface charge, which causes strong affinity to bacteria and destruction of bacterial cell walls and cell membranes. They have good chemical antibacterial effects, and the chemical antibacterial rates are above 50%. Under the irradiation of an 808 nm laser, for Gram-negative bacteria and Gram-positive bacteria, GNR@PE (50.00 μg/mL) and GNS@PE (55.00 μg/mL) can kill more than 99% of bacteria through chemo-photothermal effects. GNR@PE and GNS@PE can help eliminate inflammation caused by infection and promote wound healing in the mice model and have few side effects on the organs of mice.

中文翻译：

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聚电解质功能化金纳米材料的协同化学-光热抗菌作用

随着细菌感染对人类健康的威胁越来越大，开发不同的抗菌药物至关重要。因此，基于金纳米材料的光热转换特性，设计合成了聚电解质（PE）包覆的金纳米棒（GNR@PE）和金纳米星（GNS@PE）。因此，实现了化学-光热协同抗菌作用。GNR@PE有效消除了十六烷基三甲基溴化铵（CTAB）的高毒性，GNR@PE和GNS@PE均具有良好的生物相容性和稳定性。由于阳离子涂层，GNR@PE 和 GNS@PE 显示出较高的局部表面电荷，这导致对细菌的强亲和力和细菌细胞壁和细胞膜的破坏。具有良好的化学抑菌效果，化学抑菌率达50%以上。在 808 nm 激光照射下，对于革兰氏阴性菌和革兰氏阳性菌，GNR@PE (50.00 μg/mL) 和 GNS@PE (55.00 μg/mL) 可以化学杀灭 99% 以上的细菌。光热效应。GNR@PE和GNS@PE在小鼠模型中可以帮助消除感染引起的炎症，促进伤口愈合，对小鼠器官几乎没有副作用。