Considering the increasing incidence of fatal aluminium phosphide (ALP) poisoning and its toxicological aspects and also the paucity of our knowledge concerning the ALP effect on adipose tissue and adipokines, the present study aimed to assess the effect of acute and sub-chronic ALP inhalation exposure on adipose tissue characteristics and histological alterations in rats. This experimental study was performed on 40 male Wistar rats weighing 150–200 g. They were randomly divided into four groups (n = 10) including inhalation exposure groups to 5.67 mg/m³ (2.4 ppm) ALP for 6 h, one week and four weeks, respectively, and a control group. At the beginning and end of the study, body weight and fasting blood sugar (FBS) of animals were determined. Then, the animals were anaesthetized. The specimens of perirenal and visceral (perigonadal) adipose tissues by the routine histological process for haematoxylin and eosin (H&E) staining were determined. The results showed that the histopathological alteration of adipose tissue was significantly different between the study groups (p < 0.05). Compared to the control group, the numbers of adipocytes in perirenal area were dramatically increased in 6 h ALP exposure(p < 0.001). In agreement with the cell number changes, cell size in the perirenal area in the 6h-ALP group was markedly lower than control group (p < 0.001). Meanwhile, there was no statistically difference in the cell number of adipocytes in gonadal area between control and 6h-ALP groups(p = 0.071). Final FBS increased significantly in 6-h and 4 weeks compared to the control group (p < 0.0001). Total cholesterol and triglyceride levels decreased significantly in 4 weeks and 6h-ALP exposure in comparison with the control group (p < 0.0001) also, LDL and HDL levels in 6 h and 4 weeks’ ALP exposure and in 4 weeks ALP exposure had a significant decrease compared with the control group, respectively (p = 0.03 and p = 0.001 and p < 0.0001). ALP poisoning had a significant association with alterations in physiological and histological parameters.

考虑到致命的磷化铝（ALP）中毒的发生率及其毒理学方面的增加，以及我们对ALP对脂肪组织和脂肪因子的影响的认识不足，因此，本研究旨在评估急性和亚慢性ALP吸入暴露的影响对大鼠脂肪组织特征和组织学改变的影响 这项实验研究是对40只体重150-200 g的雄性Wistar大鼠进行的。他们被随机分为四组（n  = 10），包括5.67 mg / m ^3的吸入暴露组。（2.4 ppm）ALP分别为6小时，1周和4周，以及对照组。在研究的开始和结束时，确定动物的体重和空腹血糖（FBS）。然后，将动物麻醉。通过常规组织学方法对苏木精和曙红（H＆E）染色，确定肾周和内脏（腹膜）脂肪组织的标本。结果表明，各研究组之间脂肪组织的组织病理学变化有显着差异（p  <0.05）。与对照组相比，ALP暴露6 h后肾周区域的脂肪细胞数量显着增加（p < 0.001）。与细胞数量的变化一致，6h-ALP组肾周区域的细胞大小显着低于对照组（p <  0.001）。同时，对照组和6h-ALP组在性腺区域的脂肪细胞数量没有统计学差异（p  = 0.071）。与对照组相比，最终FBS在6小时和4周内显着增加（p <  0.0001）。与对照组相比，第4周和第6h-ALP暴露的总胆固醇和甘油三酯水平也显着降低（p <  0.0001），第6和第4周ALP暴露和第4周的LDL和HDL水平也显着降低。与对照组相比分别降低（p  = 0.03和p  = 0.001和p <  0.0001）。ALP中毒与生理和组织学参数的改变有显着关联。