ABSTRACT

The TNFα G308A gene polymorphism has been reported to influence performance impairment during total sleep deprivation (TSD). We investigated this effect in a randomized, double-blind, crossover laboratory study of repeated exposure to 48 h TSD with caffeine administration at different doses. In a retrospective analysis, we replicated the finding that the A allele of TNFα G308A, found in 4 of 12 study participants, confers resilience to performance impairment during TSD. There was no evidence of an interaction of TNFα genotype with the beneficial effect of caffeine (200 or 300 mg) on performance during TSD, suggesting distinct underlying mechanisms.

摘要

该TNFα G308A基因多态性已报告总睡眠剥夺（TSD）过程中影响性能的损害。我们在一项随机，双盲，交叉实验室研究中研究了这种作用，该研究反复暴露于48 h TSD并以不同剂量的咖啡因进行给药。在一项回顾性分析中，我们复制了这一发现的等位基因TNFα G308A，在4月12日的研究对象发现，赋予TSD期间抵御性能受损。没有证据表明TNFα基因型与咖啡因（200或300 mg）对TSD期间表现的有益作用之间存在相互作用，表明存在不同的潜在机制。