ABSTRACT

Introduction

Biofilm is a layer of mucilage consisting of bacterial species like Escherichia coli and Streptococcus aureus adhering to the solid cell surface. Biofilm is an important and novel approach in a delivery system consisting of six elements that includes extracellular DNA, enzymes, proteins, bacteria, exopolysaccharides and water channels. The biofilm formation is based on two mechanisms: extra polymeric substance and quorum sensing. The microbes present in biofilm prevent direct interaction between the cell surface and foreign materials, like allergens, or toxic gases, like carbon-monoxide and chlorofluorocarbon, entering the body.

Areas covered

The authors focus on the novel applications of biofilms such as adhesives, tissue engineering, targeted delivery system, probiotics, nutrients delivery, etc. Moreover, the information of the factors for biofilm formation, techniques useful in biofilm formation, and clinical studies are also covered in this article.

Expert opinion

Many people believe that biofilms have a negative impact on human health, but the expert opinion states that biofilm is a futuristic approach useful in therapeutics for the treatment of tumors and cancer. Biofilms can be combined with novel delivery systems such as nanoparticles, microparticles, etc. for better therapeutic action.

中文翻译：

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生物膜疗法的战略进展和多模式应用

摘要

介绍

生物膜是一层粘液，由粘附在固体细胞表面的细菌物种组成，如大肠杆菌和金黄色葡萄球菌。生物膜是一种重要且新颖的传递系统，由六种元素组成，包括细胞外 DNA、酶、蛋白质、细菌、胞外多糖和水通道。生物膜的形成基于两种机制：额外的聚合物物质和群体感应。生物膜中存在的微生物可防止细胞表面与进入体内的外来物质（如过敏原）或有毒气体（如一氧化碳和氯氟烃）之间的直接相互作用。

覆盖区域

作者专注于生物膜的新应用，如粘合剂、组织工程、靶向递送系统、益生菌、营养物递送等。此外，还涵盖了生物膜形成因素、生物膜形成技术和临床研究等信息。在本文中。

专家意见

许多人认为生物膜对人类健康有负面影响，但专家意见指出，生物膜是一种可用于治疗肿瘤和癌症的未来方法。生物膜可以与新型递送系统（如纳米颗粒、微粒等）相结合，以获得更好的治疗效果。