ABSTRACT CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy. ⁣Recently, CD47 has been shown to play a role as a signaling receptor, involving a number of cell physiological processes.⁣⁣ This review provides a comprehensive survey of the signaling pathways triggered by CD47 ligand-mediated cell death in tumor cells. Such an understanding should lead to improvement of CD47-targeted anti-tumor therapeutics able to both neutralize the anti-phagocytic role and trigger autonomous tumor cell death.

中文翻译：

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CD47（分化簇 47）：一种具有多种信号功能的抗吞噬受体

摘要 CD47 是一种肿瘤相关抗原，以其作为免疫逃避策略结合专业吞噬细胞表面的反受体的能力而闻名。最近，CD47 已被证明作为信号受体发挥作用，涉及许多细胞生理过程。该综述对肿瘤细胞中由 CD47 配体介导的细胞死亡触发的信号通路进行了全面调查。这种理解应该会导致 CD47 靶向抗肿瘤疗法的改进，既能中和抗吞噬作用，又能触发自主肿瘤细胞死亡。