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Effects of sex and menstrual cycle on volume regulatory responses to 24-h fluid restriction.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology ( IF 2.2 ) Pub Date : 2020-09-16 , DOI: 10.1152/ajpregu.00173.2020
Gabrielle E W Giersch 1, 2 , Abigail T Colburn 3 , Margaret C Morrissey 2 , Cody R Butler 2 , Michaela L Pruchnicki 2 , Stavros A Kavouras 3 , Nisha Charkoudian 1 , Douglas J Casa 2
Affiliation  

Reproductive hormones can have significant non-reproductive physiological effects, including altering the regulation of body fluid volume. The purpose of this investigation was to explore the impact of sex and menstrual cycle (MC) phase on volume regulatory responses to 24-hour fluid restriction (24-h FR). Participants (men: n=12, 20±2y; women: n=10, 20±1y) were assigned two randomized and counterbalanced fluid prescriptions (Euhy: euhydrated, urine specific gravity, USG<1.020; Dehy: 24-h FR, USG>1.020). Men completed both (MEuhy, MDehy) while women completed both in the late follicular (days 10-13; FDehy, FEuhy) and mid-luteal (days 18-22; LDehy, LEuhy) phases. We measured body mass, plasma and urine osmolality (Posm, Uosm), USG, urine color (Ucol) and serum copeptin. 24-h FR yielded mild dehydration with no influence of sex or MC phase (P>0.05). Men exhibited higher copeptin following Dehy (pre: 8.2±5.2, post: 15.8±12.6, P=0.04) but women did not (FDehy - pre: 4.3±1.6, post: 10.5±6.9, P=0.06; LDehy - pre: 5.6±3.5, post: 10.4±6.2, P=0.16). In FDehy women, Posm increased following FR (pre: 288±2, post: 292±1, P=0.03) but not in men (pre: 292±3, post: 293±2, P=0.46). No MC differences were observed between %BML, Posm, Uosm, USG, Ucol, and serum copeptin (P>0.05). These results suggest that copeptin responses to mild dehydration elicited via 24-h FR were present in men only, regardless of MC phase in young healthy adults.

中文翻译:

性别和月经周期对 24 小时液体限制的容量调节反应的影响。

生殖激素可能具有显着的非生殖生理效应,包括改变体液量的调节。本次调查的目的是探讨性别和月经周期 (MC) 阶段对 24 小时液体限制 (24-h FR) 的容量调节反应的影响。参与者(男性:n=12、20±2y;女性:n=10、20±1y)被分配了两种随机和平衡的液体处方(Euhy:水合,尿比重,USG<1.020;Dehy:24-h FR, USG>1.020)。男性完成了这两个阶段(MEuhy,MDehy),而女性完成了卵泡晚期(第 10-13 天;FDehy,FEuhy)和黄体中期(第 18-22 天;LDehy,LEuhy)阶段。我们测量了体重、血浆和尿液渗透压 (P osm , U osm )、USG、尿液颜色 (U col) 和血清和肽素。24 小时 FR 产生轻度脱水,不受性别或 MC 阶段的影响(P>0.05)。男性在 Dehy 后表现出更高的和肽素(前:8.2±5.2,后:15.8±12.6,P=0.04)但女性没有(FDehy - 前:4.3±1.6,后:10.5±6.9,P=0.06;LDehy - 前: 5.6±3.5,后:10.4±6.2,P=0.16)。在 FDehy 女性中,P osm在 FR 后增加(前:288±2,后:292±1,P=0.03),但在男性中没有(前:292±3,后:293±2,P=0.46)。在 %BML、P osm、U osm、USG、U col和血清和肽素之间未观察到 MC 差异(P>0.05)。这些结果表明,和肽素对通过 24 小时 FR 引起的轻度脱水的反应仅存在于男性中,无论年轻健康成人的 MC 阶段如何。
更新日期:2020-09-16
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