Several epidemiological and immunological studies indicate a reciprocal association between obesity/metabolic syndrome and helminth infections. Numerous studies demonstrated that obesity is concomitant with chronic low-grade inflammation, which is marked by vital changes in cellular composition and function of adipose tissue. However, the effect of helminth infection on the homeostatic milieu in obesity is not well-understood. To determine the relationship between Strongyloides stercoralis (Ss) infection and obesity, we examined an array of parameters linked with obesity both before and at 6 months following anthelmintic treatment. To this end, we measured serum levels of pancreatic hormones, incretins, adipokines and Type-1, Type-2, Type-17, and other proinflammatory cytokines in those with non-diabetic obesity with (INF) or without Ss infection (UN). In INF individuals, we evaluated the levels of these parameters at 6 months following anthelmintic treatment. INF individuals revealed significantly lower levels of insulin, glucagon, C-peptide, and GLP-1 and significantly elevated levels of GIP compared to UN individuals. INF individuals also showed significantly lower levels of Type-1, Type-17 and other pro-inflammatory cytokines and significantly increased levels of Type-2 and regulatory cytokines in comparison to UN individuals. Most of these changes were significantly reversed following anthelmintic treatment. Ss infection is associated with a significant alteration of pancreatic hormones, incretins, adipokines, and cytokines in obese individuals and its partial reversal following anthelmintic treatment. Our data offer a possible biological mechanism for the protective effect of Ss infection on obesity.

几项流行病学和免疫学研究表明，肥胖/代谢综合征和蠕虫感染之间存在相互关系。大量研究表明，肥胖症伴有慢性低度炎症，其特征是细胞组成和脂肪组织功能发生重大变化。但是，对于肥胖中的稳态环境，蠕虫感染的影响还没有被很好地理解。确定之间的关系甾体类固醇（Ss）感染和肥胖，我们在驱虫药治疗之前和之后的6个月检查了一系列与肥胖相关的参数。为此，我们对患有非糖尿病性肥胖症且患有（INF）或不患有（INF）的肥胖者，测量了其血清激素，胰降血糖素，脂肪因子以及1型，2型，17型和其他促炎细胞因子的水平。s感染（联合国）。在INF个体中，我们评估了驱虫治疗后6个月这些参数的水平。与联合国个人相比，INF个体显示胰岛素，胰高血糖素，C肽和GLP-1的水平显着降低，而GIP的水平显着升高。与联合国个人相比，INF个体还显示出明显降低的1型，17型和其他促炎细胞因子水平，以及2型和调节性细胞因子水平显着上升。驱虫治疗后，大多数这些变化均被显着逆转。s感染与肥胖个体中胰腺激素，肠降血糖素，脂肪因子和细胞因子的显着改变及其驱虫治疗后的部分逆转有关。我们的数据提供了可能的保护作用的生物学机制。s 肥胖感染。