Formal [3+2] Annulation of Copper‐Allenylidenes with 3‐Oxo‐3‐Arylpropanenitriles: Synthesis of Tetrasubstituted Furans,Advanced Synthesis & Catalysis

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Formal [3+2] Annulation of Copper‐Allenylidenes with 3‐Oxo‐3‐Arylpropanenitriles: Synthesis of Tetrasubstituted Furans
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-09-16 , DOI: 10.1002/adsc.202000929
De Zhong ₁ , Feng Jiang ₁ , Siyong Shen ₁ , Lan Wang ₁ , Wei Wang ₂ , Yongjun Wu ₂ , Yumei Xiao ₁ , Hongchao Guo ₁

Affiliation

The copper‐catalyzed decarboxylative [3+2] annulation of ethynyl benzoxazinanones with 3‐oxo‐3‐arylpropanenitriles has been developed, producing tetrasubstituted furan derivatives in moderate to high yield. This reaction was generally compatible with a wide range of substrates. Notably, the intermediate copper‐allenylidenes worked as a C2 synthon in the cycloaddition reaction.

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