Despite the peripheral nervous systems (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promise in augmenting endogenous PNS regeneration following PNI. Clinical trials utilizing neurotrophic factors for other indications (eg, peripheral neuropathy) may provide insight into their role in PNI. Here we provide an updated review of progress made toward enhancing regeneration after PNI with a focus on neurotrophic factors and bioengineered scaffolds.

中文翻译：

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用神经营养因子和生物工程支架增强周围神经再生：基础科学和临床观点。

尽管外周神经系统 (PNS) 具有再生能力，但外周神经损伤 (PNI) 后的功能恢复变化很大，通常会导致持续的功能缺陷。在临床前领域，外源性神经营养因子的治疗应用和合成神经支架技术的进步有望增加 PNI 后的内源性 PNS 再生。使用神经营养因子治疗其他适应症（如周围神经病变）的临床试验可能有助于深入了解它们在 PNI 中的作用。在这里，我们提供了在增强 PNI 后再生方面取得的进展的最新评论，重点是神经营养因子和生物工程支架。