Implant‐associated soft tissue infections at the skin‐implant interface represent the most frequent complications in reconstructive surgery and lead to implant failures and revisions. Titanium implants with deep porosity, called skin‐and‐bone‐integrated‐pylons (SBIP), allow for skin ingrowth in the morphologically natural direction, thus restoring a reliable dermal barrier and reducing the risk of infection. Silver coating of the SBIP implant surface using physical vapor deposition technique offers the possibility of preventing biofilm formation and exerting a direct antimicrobial effect during the wound healing phase. In vivo studies employing pig and rabbit dorsum models for assessment of skin ingrowth into the pores of the pylon demonstrated the safety of transcutaneous implantation of the SBIP system. No postoperative complications were reported at the end of the follow‐up period of 6 months. Histological analysis proved skin ingrowth in the minipig model without signs of silver toxicity. Analysis of silver release (using energy dispersive X‐ray spectroscopy) in the model of intramedullary‐inserted silver‐coated SBIP in New Zealand rabbits demonstrated trace amounts of silver after 3 months of in‐bone implantation. In conclusion, selected temporary silver coating of the SBIP implant surface is powerful at preventing the periprosthetic infections without imparing skin ingrowth and can be considered for clinical application.

中文翻译：

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在猪和兔的背部模型中使用经皮镀银的皮肤和骨骼集成挂架保护皮肤植入物界面

皮肤-种植体界面的种植体相关软组织感染是重建手术中最常见的并发症，并导致种植体失败和翻修。具有深孔的钛植入物，称为皮肤和骨骼集成塔（SBIP），允许皮肤在形态自然方向上向内生长，从而恢复可靠的皮肤屏障并降低感染风险。SBIP 植入物表面的银涂层使用物理气相沉积技术提供了防止生物膜形成并在伤口愈合阶段发挥直接抗菌作用的可能性。采用猪和兔背部模型评估皮肤向塔孔内生长的体内研究证明了经皮植入 SBIP 系统的安全性。在 6 个月的随访期结束时未报告术后并发症。组织学分析证明小型猪模型中的皮肤向内生长，没有银毒性迹象。银释放分析（使用能量色散 X 射线光谱)在新西兰兔的髓内植入银涂层 SBIP 模型中，在骨内植入 3 个月后显示出痕量的银。总之，选择的 SBIP 植入物表面的临时银涂层可有效防止假体周围感染，而不会影响皮肤向内生长，可考虑用于临床应用。