Neonicotinoids are a widely used class of pesticides. Co‐exposure to neonicotinoids and other classes of pesticides can exert potentiating or synergistic effects, and these mixtures have been detected in human bodily fluids. The present review summarizes studies into the effects of neonicotinoid‐containing pesticide mixtures on humans and other nontarget organisms. Exposure to these mixtures has been reported to result in reproductive and hormonal toxicity, genotoxicity, neurotoxicity, hepatotoxicity, and immunotoxicity in vertebrates. Mortality of pollinators and toxicity in other organisms has also been reported. The underlying mechanism of pesticide mixture toxicity may be associated with impairment of cytochrome 450 enzymes, which are involved in metabolizing pesticides. However, a comprehensive explanation of the adverse effects of neonicotinoid‐containing pesticide mixtures is still required so that effective prevention and control measures can be formulated. Environ Toxicol Chem 2020;39:1884–1893. © 2020 SETAC

中文翻译：

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含新烟碱类农药混合物对非目标生物的毒性。

新烟碱是一种广泛使用的农药。同时接触新烟碱类农药和其他类别的农药可产生增效作用或协同作用，并且这些混合物已在人体液中检测到。本综述总结了含新烟碱类农药混合物对人类和其他非目标生物的影响的研究。据报道，暴露于这些混合物会导致脊椎动物的生殖和激素毒性，遗传毒性，神经毒性，肝毒性和免疫毒性。传粉者的死亡率和其他生物的毒性也已有报道。农药混合物毒性的潜在机制可能与细胞代谢中农药参与的细胞色素450酶的损伤有关。然而，环境毒性化学2020； 39：1884–1893。©2020 SETAC