A Concise Review of Baseline Facts of SARS‐CoV‐2 for Interdisciplinary Research,ChemistrySelect

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A Concise Review of Baseline Facts of SARS‐CoV‐2 for Interdisciplinary Research
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-09-16 , DOI: 10.1002/slct.202002420
Adish Tyagi ₁ , Sandeep Nigam ₁ , Rohit Singh Chauhan ₂

Affiliation

The COVID‐19 pandemic caused by SARS‐CoV‐2 is a global health emergency. Investigation covering various aspects of diagnosis, treatment, and vaccine development for COVID‐19 are being attempted globally. Common goal of reducing loss of life requires accelerated and integrated effort from researchers of different fields i. e. chemistry, biology, clinical/medical science etc. Integrated yet timely effort requires the understanding of interdisciplinary key concepts as well as knowledge of major challenges, present status and strategies. Hence, in this article, we present an overview of baseline/key facts of SARS‐CoV‐2 mingled with current status and strategies in a simple, straight forward and coherent manner. In particular, the review attempts to integrate and arrange the key facts at the interface of chemistry and biology. Overview of epidemiology of SARS‐CoV‐2 virus infection, structural characteristics of virus, detection methods and therapeutic agents based on antibodies, therapeutic agents based on traditional drug molecule, drug development based on specific catalytic enzyme inhibitors, vaccine design approaches have been provided. Since enzyme site and catalytic action is the key for biological process, they have been lucidly explained at molecular level. It is believed that accredited information amalgamated in this report will provide a strong rational and lucid groundwork for the coherent interdisciplinary research to countermeasure covid‐19 crisis.

中文翻译：

简要回顾一下SARS-CoV-2的基线事实，以进行跨学科研究

SARS-CoV-2引起的COVID-19大流行是全球性的突发卫生事件。目前正在全球范围内进行针对COVID-19的诊断，治疗和疫苗开发各个方面的调查。减少生命损失的共同目标需要来自不同领域的研究人员加速和综合的努力。e。化学，生物学，临床/医学等。综合而及时的工作需要了解跨学科的关键概念以及对重大挑战，现状和策略的了解。因此，在本文中，我们以简单，直接，连贯的方式概述了SARS-CoV-2的基线/关键事实，将其与当前状态和策略混合在一起。特别是，该综述试图在化学和生物学的界面上整合和整理关键事实。已提供了SARS-CoV-2病毒感染的流行病学概述，病毒的结构特征，基于抗体的检测方法和治疗剂，基于传统药物分子的治疗剂，基于特定催化酶抑制剂的药物开发，疫苗设计方法。由于酶的位点和催化作用是生物过程的关键，因此在分子水平上对它们进行了清楚的解释。可以相信，本报告中合并的经过认可的信息将为针对跨学科的covid-19危机的连贯跨学科研究提供强有力的理性和清晰的基础。基于特定催化酶抑制剂的药物开发，已经提供了疫苗设计方法。由于酶的位点和催化作用是生物过程的关键，因此在分子水平上对它们进行了清楚的解释。相信本报告中合并的经过认可的信息将为针对跨学科的covid‐19危机的连贯跨学科研究提供强有力的理性和清晰的基础。基于特定催化酶抑制剂的药物开发，已经提供了疫苗设计方法。由于酶的位点和催化作用是生物过程的关键，因此在分子水平上对它们进行了清楚的解释。可以相信，本报告中合并的经过认可的信息将为针对跨学科的covid-19危机的连贯跨学科研究提供强有力的理性和清晰的基础。

更新日期：2020-09-16

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