Facile Stereoselective Reduction of Prochiral Ketones using an F420-dependent alcohol dehydrogenase.,ChemBioChem

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Facile Stereoselective Reduction of Prochiral Ketones using an F420-dependent alcohol dehydrogenase.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-16 , DOI: 10.1002/cbic.202000651
Caterina Martin ₁ , Gwen Tjallinks ₁ , Milos Trajkovic ₁ , Marco W Fraaije ₁

Affiliation

An alternative to NADH dependence: An F₄₂₀‐dependent alcohol dehydrogenase can be used to asymmetrically reduce prochiral ketones. Conveniently, using a cheap sacrificial cosubstrate (isopropanol), the same enzyme can regenerate the deazaflavin cofactor.