Nanofactories for Controlled Synthesis and Delivery of Nucleoside Analogue Therapeutics.,ChemBioChem

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Nanofactories for Controlled Synthesis and Delivery of Nucleoside Analogue Therapeutics.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-16 , DOI: 10.1002/cbic.202000382
Kourosh H Ebrahimi ₁

Affiliation

A visionary nanofactory: A nanofactory for the in situ synthesis and targeted delivery of a nucleoside therapeutic is envisioned. It requires an engineered form of a radical‐SAM enzyme, is functionalized with a multicopper oxidase to generate anaerobic microenvironment, and uses a flavodoxin–flavodoxin reductase system to supply electrons for catalysis.