Stapled Peptide Inhibitors of Autophagy Adapter LC3B,ChemBioChem

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Stapled Peptide Inhibitors of Autophagy Adapter LC3B
ChemBioChem ( IF 2.6 ) Pub Date : 2020-09-16 , DOI: 10.1002/cbic.202000636
Robert A. Cerulli ₁ , Livia Shehaj ₂ , Hawley Brown ₂ , Jennifer Pace ₂ , Yang Mei ₂ , Joshua A. Kritzer ₂

Affiliation

For natural ligands of the human autophagy adaptor protein LC3B, the key recognition motif binds in an extended conformation (upper left). We report extensive structure–activity relationships for this important protein–protein interaction. We also used this information to design an artificial “staple” (shown in orange) that improves the binding and biological properties of the ligand peptides. More information can be found in the full paper by J. A. Kritzer et al.

中文翻译：

自噬衔接子LC3B的装好的肽抑制剂

对于人类自噬衔接蛋白LC3B的天然配体，关键识别基序以扩展构象结合（左上）。我们报告了这种重要的蛋白质-蛋白质相互作用的广泛的结构-活性关系。我们还使用此信息设计了可改善配体肽的结合和生物学特性的人工“主食”（以橙色显示）。可以在J. A. Kritzer等人的全文中找到更多信息。

更新日期：2020-10-02

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