Tandem catalysis capable of completing multistep reactions in a single pot or step is an effective strategy to develop cost-effective and environmentally benign chemical processes. A unique challenge in the selectivity control of tandem reactions is the coexistence of reactants, intermediates, and products from all constituent steps in the same reaction medium, causing side reactions. Thus, distinct catalyst design principles are needed. In this review, we introduce four design concepts for tandem catalysts, comprising engineering of the spatial distribution of catalytic sites, the molecular proximity of sites, the nature of sites, and the size of the pores in which sites reside. Current challenges and opportunities for future research in tandem catalysis are also discussed.

能够在一个罐或一个步骤中完成多步反应的串联催化是开发具有成本效益且对环境无害的化学过程的有效策略。串联反应选择性控制中的一个独特挑战是，来自所有组成步骤的反应物，中间体和产物在同一反应介质中共存，从而引起副反应。因此，需要不同的催化剂设计原理。在这篇综述中，我们介绍了串联催化剂的四个设计概念，包括对催化位点的空间分布，位点的分子接近度，位点的性质以及位点所在的孔的大小进行设计。还讨论了目前在串联催化研究中的挑战和机遇。