Abstract The enormous demand for daily diagnosis of glucose has encouraged the quest for rapid, reliable, and low-cost glucose detection strategies. In this work, the synergic effect of cobalt oxide (Co3O4) nanoparticles and reduced graphene oxide (rGO) nanosheets were used for electrocatalytic oxidation of glucose on glassy carbon electrodes (GCE). The synthesized nanocomposite was fully characterized using X-ray diffractometry, Fourier transform infrared spectroscopy (FTIR), UV–vis spectroscopy, field emission scanning electron microscopy (FE-SEM) with elemental analysis and dynamic light scattering (DLS). The electrochemical performance of the rGO/Co3O4 nanoparticle-modified electrode for enzyme-free detection of glucose was evaluated using cyclic voltammetry (CV). The developed sensor showed an excellent sensitivity towards glucose with the limit of detection (LOD) as low as 3.6 nM in low response time (5 s). The ability of the developed sensor for the detection of glucose in real sample analysis confirmed its potential application in rapid and accurate daily diagnosis of glucose.

中文翻译：

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用氧化钴纳米粒子装饰的还原氧化石墨烯纳米片：一种用于葡萄糖检测的非酶电化学方法

摘要 对葡萄糖日常诊断的巨大需求促使人们寻求快速、可靠和低成本的葡萄糖检测策略。在这项工作中，氧化钴 (Co3O4) 纳米颗粒和还原氧化石墨烯 (rGO) 纳米片的协同作用被用于葡萄糖在玻碳电极 (GCE) 上的电催化氧化。使用 X 射线衍射、傅里叶变换红外光谱 (FTIR)、紫外-可见光谱、场发射扫描电子显微镜 (FE-SEM)、元素分析和动态光散射 (DLS) 对合成的纳米复合材料进行了全面表征。使用循环伏安法 (CV) 评估了用于无酶检测葡萄糖的 rGO/Co3O4 纳米颗粒修饰电极的电化学性能。开发的传感器对葡萄糖表现出极好的灵敏度，检测限 (LOD) 在低响应时间 (5 s) 下低至 3.6 nM。开发的传感器在实际样品分析中检测葡萄糖的能力证实了其在快速准确的日常葡萄糖诊断中的潜在应用。