Aquatic contamination from the accumulation of pharmaceuticals has induced severe toxicological impact to the ecological environment, especially from non-steroidal anti-inflammatory drugs (NSAIDs). Real-time monitoring of flutamide, which is a class of NSAIDs, is very significant in environmental protection. In this work, we have synthesized the hexagonal-h boron nitride decorated on bismuth oxide (Bi₂O₃/h-BN) based nanocomposite for the effective electrochemical detection of flutamide (FTM). The structural and morphological information of the heterostructured Bi₂O₃/h-BN nanocomposite was analyzed by using a sequence of characterization methods. Voltammetric techniques were used to evaluate the analytical performance of the Bi₂O₃/h-BN modified screen-printed carbon electrode (SPCE) for the FTM detection. The Bi₂O₃/h-BN modified SPCE displays a synergetic catalytic effect for the reduction of FTM due to large surface area, numerous active sites, fast charge transfer and abundant defects. The proposed electrochemical sensing platform demonstrates high selectivity, low detection limit (9.0 nM), good linear ranges (0.04–87 μM) and short response time for the detection of FTM. The feasibility of the electrochemical sensor has been proved by the successful application to determine FTM in environmental samples.

药物积累引起的水生污染已对生态环境产生了严重的毒理学影响，尤其是非甾体类抗炎药（NSAID）。非甾体类抗炎药一类的氟他胺的实时监测在环境保护方面非常重要。在这项工作中，我们合成了装饰在基于氧化铋（Bi ₂ O ₃ / h-BN）的纳米复合材料上的六方晶-h氮化硼，用于有效电化学检测氟他胺（FTM）。通过一系列表征方法分析了异结构Bi ₂ O ₃ / h-BN纳米复合材料的结构和形态信息。伏安技术用于评估铋的分析性能₂ O ₃ / h-BN修饰的丝网印刷碳电极（SPCE），用于FTM检测。Bi ₂ O ₃ / h-BN改性的SPCE由于表面积大，活性位点多，电荷转移快和缺陷多而对FTM的还原具有协同催化作用。拟议的电化学传感平台展示出高选择性，低检测限（9.0 nM），良好的线性范围（0.04–87μM）和较短的FTM检测响应时间。电化学传感器的可行性已通过在环境样品中测定FTM的成功应用得到证明。