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Probabilistic health risk assessment of occupational exposure to isoflurane and sevoflurane in the operating room.
Ecotoxicology and Environmental Safety ( IF 6.2 ) Pub Date : 2020-09-16 , DOI: 10.1016/j.ecoenv.2020.111270
Fatemeh Dehghani 1 , Mojtaba Kamalinia 1 , Fariborz Omidi 2 , Reza Ali Fallahzadeh 3
Affiliation  

Risk assessment is an important tool in predicting the possible risk to health. It heightens awareness by estimating the probability of adverse health effects in humans who are exposed to chemicals in the course of their work. Therefore, the present work aims to determine the occupational exposure of operating room staff to the volatile anesthetic gases, isoflurane and sevoflurane, and estimates non-cancer risk using the United States Environmental Protection Agency method. Air samples from the breathing zone of staff members were collected using the Occupational Safety and Health Administration Method 103 and analyzed using gas chromatography-mass spectroscopy. The results indicate that the measured concentrations of isoflurane and sevoflurane are below the National Institute of Occupational Safety and Health standard (2 ppm) for technicians and nurses, but not for anesthesiologists and surgeons. Moreover, the estimated non-cancer risk due to isoflurane is above the acceptable value for anesthesiologists (but acceptable for other occupational categories). A sensitivity analysis indicates that exposure time has the most effect on calculated risk (53.4%). Occupational exposure to anesthetic gases may endanger the health of operating room personnel. Therefore, control measures, such as daily testing of anesthetic devices, ensuring the effectiveness of ventilation systems, advanced scavenging methods, and regular training of staff are highly recommended.



中文翻译:

在手术室中职业性接触异氟烷和七氟醚的概率健康风险评估。

风险评估是预测健康风险的重要工具。通过估计在工作过程中接触化学物质的人类健康对健康造成不利影响的可能性,它可以提高人们的认识。因此,本工作旨在确定手术室工作人员在挥发性麻醉气体,异氟烷和七氟醚中的职业暴露程度,并使用美国环境保护署的方法估算非癌症风险。使用“职业安全与健康管理局方法” 103收集工作人员呼吸区的空气样品,并使用气相色谱-质谱法进行分析。结果表明,对于技术人员和护士,异氟烷和七氟醚的测量浓度低于美国国家职业安全与健康研究所的标准(2 ppm),但对于麻醉师和外科医生而言则不然。此外,由异氟烷引起的估计非癌症风险高于麻醉师可接受的值(但对于其他职业类别则可接受)。敏感性分析表明,接触时间对计算出的风险影响最大(53.4%)。职业性接触麻醉气体可能危害手术室人员的健康。因此,强烈建议采取控制措施,例如麻醉设备的日常测试,确保通风系统的有效性,先进的清除方法以及对员工进行定期培训。此外,由异氟烷引起的估计非癌症风险高于麻醉医师可接受的值(但对于其他职业类别则可接受)。敏感性分析表明,接触时间对计算出的风险影响最大(53.4%)。职业性接触麻醉气体可能危害手术室人员的健康。因此,强烈建议采取控制措施,例如麻醉设备的日常测试,确保通风系统的有效性,先进的清除方法以及对员工进行定期培训。此外,由异氟烷引起的估计非癌症风险高于麻醉医师可接受的值(但对于其他职业类别则可接受)。敏感性分析表明,接触时间对计算出的风险影响最大(53.4%)。职业性接触麻醉气体可能危害手术室人员的健康。因此,强烈建议采取控制措施,例如麻醉设备的日常测试,确保通风系统的有效性,先进的清除方法以及对员工进行定期培训。职业性接触麻醉气体可能危害手术室人员的健康。因此,强烈建议采取控制措施,例如麻醉设备的日常测试,确保通风系统的有效性,先进的清除方法以及对员工进行定期培训。职业性接触麻醉气体可能危害手术室人员的健康。因此,强烈建议采取控制措施,例如麻醉设备的日常测试,确保通风系统的有效性,先进的清除方法以及对员工进行定期培训。

更新日期:2020-09-16
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