8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.

中文翻译：

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倍半萜内酯的合成转化。11.* 基于咖啡因和 Eudesmanoides 的结合物与含 N 的接头

8-（氨基烷基氨基）咖啡因或 8-（哌嗪基）咖啡因是通过使用微波辅助有机合成使 8-溴或 8-氯咖啡因与线性和环状二胺反应以高产率形成的。这些胺在与含有活性亚甲基的倍半萜内酯的迈克尔反应中具有高度反应性。合成了咖啡因和eudesmanolide 部分通过含N 接头键合的共轭物。