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Ongoing Electroencephalographic Rhythms Related to Exploratory Movements in Transgenic TASTPM Mice.
Journal of Alzheimer’s Disease ( IF 3.4 ) Pub Date : 2020-09-11 , DOI: 10.3233/jad-190351
Claudio Del Percio 1 , Wilhelmus Drinkenburg 2 , Susanna Lopez 1, 3 , Maria Teresa Pascarelli 4 , Roberta Lizio 5 , Giuseppe Noce 5 , Raffaele Ferri 4 , Jesper Frank Bastlund 6 , Bettina Laursen 6 , Ditte Zerlang Christensen 6 , Jan T Pedersen 6 , Gianluigi Forloni 7 , Angelisa Frasca 7 , Francesco M Noè 7 , Paolo Francesco Fabene 8 , Giuseppe Bertini 8 , Valeria Colavito 8 , Marina Bentivoglio 8 , Jonathan Kelley 2 , Sophie Dix 9 , Francesco Infarinato 10 , Andrea Soricelli 5, 11 , Fabrizio Stocchi 12 , Jill C Richardson 13 , Claudio Babiloni 1, 14 ,
Affiliation  

Background:The European PharmaCog study (http://www.pharmacog.org) has reported a reduction in delta (1–6 Hz) electroencephalographic (EEG) power (density) during cage exploration (active condition) compared with quiet wakefulness (passive condition) in PDAPP mice (hAPP Indiana V717F mutation) modeling Alzheimer’s disease (AD) amyloidosis and cognitive deficits. Objective:Here, we tested the reproducibility of that evidence in TASTPM mice (double mutation in APP KM670/671NL and PSEN1 M146V), which develop brain amyloidosis and cognitive deficits over aging. The reliability of that evidence was examined in four research centers of the PharmaCog study. Methods:Ongoing EEG rhythms were recorded from a frontoparietal bipolar channel in 29 TASTPM and 58 matched “wild type” C57 mice (range of age: 12–24 months). Normalized EEG power was calculated. Frequency and amplitude of individual delta and theta frequency (IDF and ITF) peaks were considered during the passive and active conditions. Results:Compared with the “wild type” group, the TASTPM group showed a significantly lower reduction in IDF power during the active over the passive condition (p < 0.05). This effect was observed in 3 out of 4 EEG recording units. Conclusion:TASTPM mice were characterized by “poor reactivity” of delta EEG rhythms during the cage exploration in line with previous evidence in PDAPP mice. The reliability of that result across the centers was moderate, thus unveiling pros and cons of multicenter preclinical EEG trials in TASTPM mice useful for planning future studies.

中文翻译:

与转基因 TASTPM 小鼠探索性运动相关的持续脑电图节律。

背景:欧洲 PharmaCog 研究 (http://www.pharmacog.org) 报告称,与安静觉醒(被动条件)在 PDAPP 小鼠(hAPP Indiana V717F 突变)中模拟阿尔茨海默病 (AD) 淀粉样变性和认知缺陷。目的:在这里,我们在 TASTPM 小鼠(APP KM670/671NL 和 PSEN1 M146V 中的双重突变)中测试了该证据的可重复性,这些小鼠随着年龄的增长会出现脑淀粉样变性和认知缺陷。PharmaCog 研究的四个研究中心检查了该证据的可靠性。方法:从 29 只 TASTPM 和 58 只匹配的“野生型”C57 小鼠(年龄范围:12-24 个月)的额顶双极通道记录持续的 EEG 节律。计算归一化 EEG 功率。在被动和主动条件下考虑了单个 delta 和 theta 频率(IDF 和 ITF)峰值的频率和幅度。结果:与“野生型”组相比,TASTPM 组在主动条件下比被动条件下的 IDF 功率降低显着更低(p < 0.05)。在 4 个 EEG 记录单元中的 3 个中观察到了这种效果。结论:TASTPM 小鼠的特征是笼探索期间 delta EEG 节律的“反应性差”,这与先前在 PDAPP 小鼠中的证据一致。该结果在各中心的可靠性中等,从而揭示了 TASTPM 小鼠多中心临床前脑电图试验的利弊,有助于规划未来的研究。结果:与“野生型”组相比,TASTPM 组在主动条件下比被动条件下的 IDF 功率降低显着更低(p < 0.05)。在 4 个 EEG 记录单元中的 3 个中观察到了这种效果。结论:TASTPM 小鼠的特征是笼探索期间 delta EEG 节律的“反应性差”,这与先前在 PDAPP 小鼠中的证据一致。该结果在各中心的可靠性中等,从而揭示了 TASTPM 小鼠多中心临床前脑电图试验的利弊,有助于规划未来的研究。结果:与“野生型”组相比,TASTPM 组在主动条件下比被动条件下的 IDF 功率降低显着更低(p < 0.05)。在 4 个 EEG 记录单元中的 3 个中观察到了这种效果。结论:TASTPM 小鼠的特征是笼探索期间 delta EEG 节律的“反应性差”,这与先前在 PDAPP 小鼠中的证据一致。该结果在各中心的可靠性中等,从而揭示了 TASTPM 小鼠多中心临床前脑电图试验的利弊,有助于规划未来的研究。TASTPM 小鼠的特征在于笼子探索期间 delta EEG 节律的“反应性差”,这与先前在 PDAPP 小鼠中的证据一致。该结果在各中心的可靠性中等,从而揭示了 TASTPM 小鼠多中心临床前脑电图试验的利弊,有助于规划未来的研究。TASTPM 小鼠的特征在于笼子探索期间 delta EEG 节律的“反应性差”,这与先前在 PDAPP 小鼠中的证据一致。该结果在各中心的可靠性中等,从而揭示了 TASTPM 小鼠多中心临床前脑电图试验的利弊,有助于规划未来的研究。
更新日期:2020-09-15
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