Background:Various reasons may lead to cognitive symptoms in elderly, including the development of cognitive decline and dementia. Often, mixed pathologies such as neurodegeneration and cerebrovascular disease co-exist in these patients. Diagnostic work-up commonly includes imaging modalities suchas FDG PET, MRI, and CT, each delivering specific information. Objective:To study the informative value of neuroimaging-based data supposed to reflect neurodegeneration (FDG PET), cerebral small vessel disease (MRI), and cerebral large vessel atherosclerosis (CT) with regard to cognitive performance in patients presenting to our memory clinic. Methods:Non-parametric partial correlations and an ordinal logistic regression model were run to determine relationships between scores for cortical hypometabolism, white matter hyperintensities, calcified plaque burden, and results from Mini-Mental State Examination (MMSE). The final study group consisted of 162 patients (female: 94; MMSE: 6– 30). Results:Only FDG PET data was linked to and predicted cognitive performance (r(157) = – 0.388, p < 0.001). Overall, parameters linked to cerebral small and large vessel disease showed no significant association with cognition. Further findings demonstrated a relationship between white matter hyperintensities and FDG PET data (r(157) = 0.230, p = 0.004). Conclusion:Only FDG PET imaging mirrors cognitive performance, presumably due to the examination’s ability to reflect neurodegeneration and vascular dysfunction, thus capturing a broader spectrum of pathologies. This makes the examination a useful imaging-based diagnostic tool in the work-up of patients presenting to a memory clinic. Parameters of vascular dysfunction alone as depicted by conventional MRI and CT are less adequate in such a situation, most likely because they reflect one pathology complex only.

中文翻译：

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FDG PET 数据与来自记忆诊所的患者的认知表现相关。

背景：多种原因可能导致老年人出现认知症状，包括认知能力下降和痴呆的发展。通常，这些患者同时存在神经变性和脑血管疾病等混合病理。诊断检查通常包括成像方式，例如 FDG PET、MRI 和 CT，每种方式都提供特定信息。目的：研究基于神经影像学数据的信息价值，这些数据旨在反映神经退行性变 (FDG PET)、脑小血管疾病 (MRI) 和脑大血管动脉粥样硬化 (CT) 在我们记忆门诊就诊的患者认知表现方面的信息价值。方法：运行非参数偏相关和有序逻辑回归模型以确定皮质低代谢、白质高信号、钙化斑块负担，以及简易精神状态检查 (MMSE) 的结果。最后的研究组由 162 名患者组成（女性：94；MMSE：6-30）。结果：只有 FDG PET 数据与认知表现相关联并对其进行预测 (r(157) = – 0.388, p < 0.001)。总体而言，与脑小血管和大血管疾病相关的参数与认知没有显着关联。进一步的研究结果表明，白质高信号与 FDG PET 数据之间存在关系（r(157) = 0.230，p = 0.004）。结论：只有 FDG PET 成像反映了认知能力，大概是由于该检查能够反映神经变性和血管功能障碍，从而捕获更广泛的病理。这使得该检查成为一种有用的基于成像的诊断工具，用于对记忆诊所就诊的患者进行检查。