Abstract: Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM. Astragalus membranaceus is a commonly used Chinese medicinal herb. Previous studies have shown that Astragalus membranaceus has anti-tumor properties and can regulate metabolism, enhance immunity, and strengthen the heart. Astragaloside IV (AS-IV) is the active ingredient of Astragalus membranaceus, which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. It can also regulate blood glucose and blood lipid levels and reduce the risk of cardiovascular diseases. In this paper, the mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.

Keywords: Astragalus membranaceus, astragaloside IV, traditional Chinese medicine, cardiovascular diseases, cardiomyocytes


中文翻译：

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黄芪甲苷IV：治疗心血管疾病的有效药物


【摘要】：心血管疾病(CVD)作为全球第一大死亡原因,一直是临床和科学研究的焦点。由于每年的死亡人数很高，因此必须找到安全有效且副作用最小的替代疗法。中医药 (TCM) 有着悠久的历史，对 CVD 的治疗产生了重大影响。药物天然活性成分的作用方式和新药开发是当前中医药研究的热点。黄芪是一种常用的中药材。前期研究表明，黄芪具有抗肿瘤作用，并能调节新陈代谢、增强免疫力、强心等作用。黄芪甲苷（AS-IV）是黄芪的活性成分，在心血管疾病中具有突出作用。 AS-IV可以保护缺血缺氧的心肌细胞损伤，抑制心肌肥厚和心肌纤维化，增强心肌收缩力，改善舒张功能障碍，缓解血管内皮功能障碍，促进血管生成。它还可以调节血糖和血脂水平，降低心血管疾病的风险。本文对近年来AS-IV干预心血管疾病的机制进行综述，以期为今后的研究和新药开发提供参考。


关键词：黄芪、黄芪甲苷、中药、心血管疾病、心肌细胞