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Disrupted intracellular redox balance with enhanced ROS generation and sensitive drug release for cancer therapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-15 , DOI: 10.1039/d0bm00765j Dongmiao Sang 1, 2, 3, 4 , Xiaofeng Li 2, 3, 4, 5 , Zhikun Xu 4, 6, 7, 8 , Huiming Lin 1, 2, 3, 4 , Changhong Guo 2, 3, 4, 5 , Fengyu Qu 1, 2, 3, 4
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-15 , DOI: 10.1039/d0bm00765j Dongmiao Sang 1, 2, 3, 4 , Xiaofeng Li 2, 3, 4, 5 , Zhikun Xu 4, 6, 7, 8 , Huiming Lin 1, 2, 3, 4 , Changhong Guo 2, 3, 4, 5 , Fengyu Qu 1, 2, 3, 4
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In this paper, a nanocomposite was constructed to achieve improved photodynamic therapy (PDT) via disrupting the redox balance in cancer cells. Firstly, Sb2Se3 nanorods were synthesized as a new photosensitizer, displaying high photothermal conversion efficiency (45.2%) and reactive oxygen species (ROS) production due to the narrow band gap (1.1 eV) and a good NIR response. Moreover, the mechanism was investigated, demonstrating that dissolved O2 and photoinduced electrons manipulated ROS generation. Then, mesoporous silica was coated outside to improve the biocompatibility and to supply abundant space for the anticancer drug (doxorubicin, DOX). The sensitive Se–Se linker was grafted outside via a silane coupling reaction to block DOX molecules in the mesopores. As we know, the Se–Se group is sensitive to GSH, which can induce Se–Se linker bond breakage and targeted drug release due to the high expression of GSH in tumor cells. What is more, the consumption of intracellular GSH can also disrupt the redox balance in cancer cells, which would promote the PDT efficiency. The high-Z element of Sb possesses a high X-ray attenuation coefficient, giving the composite high contrast in CT imaging. This is associated with thermal imaging and multi-therapy (PDT/PTT/chemotherapy) to reveal the potential application to cancer treatment.
中文翻译：
中断的细胞内氧化还原平衡，增强的ROS生成和敏感的药物释放，可用于癌症治疗
在本文中，构建了一种纳米复合材料，通过破坏癌细胞中的氧化还原平衡来实现改进的光动力疗法（PDT）。首先，合成了Sb 2 Se 3纳米棒作为新型光敏剂，由于窄的带隙（1.1 eV）和良好的近红外响应，显示出高的光热转化效率（45.2％）和活性氧（ROS）的产生。此外，对机理进行了研究，证明了溶解的O 2和光致电子操纵了ROS的产生。然后，将中孔二氧化硅涂在外部，以改善生物相容性并为抗癌药（阿霉素，DOX）提供充足的空间。敏感的Se-Se连接子通过硅烷偶联反应以阻断中孔中的DOX分子。我们知道，Se-Se组对GSH敏感，由于肿瘤细胞中GSH的高表达，Se-Se可以诱导Se-Se连接键断裂和靶向药物释放。而且，细胞内GSH的消耗还可以破坏癌细胞中的氧化还原平衡，从而提高PDT的效率。Sb的高Z元素具有高X射线衰减系数，从而在CT成像中提供了复合高对比度。这与热成像和多种疗法（PDT / PTT /化学疗法）相关联，以揭示其在癌症治疗中的潜在应用。
更新日期：2020-10-02
中文翻译：
中断的细胞内氧化还原平衡，增强的ROS生成和敏感的药物释放，可用于癌症治疗
在本文中，构建了一种纳米复合材料，通过破坏癌细胞中的氧化还原平衡来实现改进的光动力疗法（PDT）。首先，合成了Sb 2 Se 3纳米棒作为新型光敏剂，由于窄的带隙（1.1 eV）和良好的近红外响应，显示出高的光热转化效率（45.2％）和活性氧（ROS）的产生。此外，对机理进行了研究，证明了溶解的O 2和光致电子操纵了ROS的产生。然后，将中孔二氧化硅涂在外部，以改善生物相容性并为抗癌药（阿霉素，DOX）提供充足的空间。敏感的Se-Se连接子通过硅烷偶联反应以阻断中孔中的DOX分子。我们知道，Se-Se组对GSH敏感，由于肿瘤细胞中GSH的高表达，Se-Se可以诱导Se-Se连接键断裂和靶向药物释放。而且，细胞内GSH的消耗还可以破坏癌细胞中的氧化还原平衡，从而提高PDT的效率。Sb的高Z元素具有高X射线衰减系数，从而在CT成像中提供了复合高对比度。这与热成像和多种疗法（PDT / PTT /化学疗法）相关联，以揭示其在癌症治疗中的潜在应用。
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