Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection,Biomaterials Science

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Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-15 , DOI: 10.1039/d0bm01084g
Xiaoxue Hou _{1,

2,

3,

4,

5} , Lijun Yang _{1,

2,

3,

4,

5} , Jinjian Liu _{1,

2,

3,

4,

5} , Yumin Zhang _{1,

2,

3,

4,

5} , Liping Chu _{1,

2,

3,

4,

5} , Chunyan Ren _{1,

2,

3,

4,

5} , Fan Huang _{1,

2,

3,

4,

5} , Jianfeng Liu _{1,

2,

3,

4,

5}

Affiliation

Drug-resistant bacterial infections have stolen the spotlight in recent years as stubborn diseases intimidating public health, thus urgently requiring the development of innovative treatment strategies with high antibacterial efficiency and low bacterial resistance. Here, a polymeric antimicrobial with synergistic chemo-photodynamic therapy function is fabricated to combat drug-resistant bacterial infections. In this strategy, polymeric micelles based on amphiphilic poly(aspartic acid)-block-poly(ε-caprolactone) (PAsp-b-PCL) are used as nanocarriers to encapsulate a photosensitizer protoporphyrin IX (PpIX) in the micellar core, which then undergo silver nanoparticle decoration on the micellar shell through an in situ reduction method. Compared with mono-therapy, the combination of silver nanoparticle decoration and light-activatable PpIX enables the resulting polymeric antimicrobial to exert chemo-photodynamic activity to kill drug-resistant bacteria more potently in vitro. Furthermore, the prepared polymeric antimicrobials with synergistic antibacterial activity show robust eradication efficacy against subcutaneous infections induced by drug-resistant Staphylococcus aureus in a murine model. Therefore, our study provides a simple and potent strategy to realize combination therapy for eradicating drug-resistant bacterial infections.

中文翻译：

银装饰，可光激活的聚合物抗菌剂，用于耐药细菌感染的化学-光动力学联合治疗

近年来，由于顽固性疾病威胁着公共卫生，耐药细菌感染已成为人们关注的焦点，因此迫切需要开发具有高抗菌效率和低细菌耐药性的创新治疗策略。在这里，制造具有协同化学光动力疗法功能的高分子抗微生物剂来对抗耐药细菌感染。在这种策略中，基于两亲性的聚（天冬氨酸）聚合物胶束-嵌段-聚（ε -己内酯）（PAsp- b -PCL）用作纳米载体封装在胶束芯的原卟啉IX（PpIX的）光敏剂，然后通过原位在胶束壳上进行银纳米颗粒装饰还原法。与单一疗法相比，银纳米颗粒装饰和可光激活的PpIX的结合使所得的高分子抗菌剂发挥化学光动力学活性，从而在体外更有效地杀死耐药菌。此外，所制备的具有协同抗菌活性的聚合抗微生物剂在鼠模型中显示出对由耐药金黄色葡萄球菌诱导的皮下感染的强大根除功效。因此，我们的研究提供了一种简单有效的策略来实现根除耐药细菌感染的联合治疗。

更新日期：2020-11-03

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