Objective

The main purpose of the present study was to assess the risk for major revision surgery after perichondrium transplantation (PT) at a minimum of 22 years postoperatively and to evaluate the influence of patient characteristics.

Design

Primary outcome was treatment success or failure. Failure of PT was defined as revision surgery in which the transplant was removed, such as (unicondylar) knee arthroplasty or patellectomy. The functioning of nonfailed patients was evaluated using the International Knee Documentation Committee (IKDC) score. In addition, the influence of patient characteristics was evaluated.

Results

Ninety knees in 88 patients, aged 16 to 55 years with symptomatic cartilage defects, were treated by PT. Eighty knees in 78 patients were eligible for analysis and 10 patients were lost to follow-up. Twenty-eight knees in 26 patients had undergone major revision surgery. Previous surgery and a longer time of symptoms prior to PT were significantly associated with an increased risk for failure of cartilage repair. Functioning of the remaining 52 patients and influence of patient characteristics was analyzed using their IKDC score. Their median IKDC score was 39.08, but a relatively young age at transplantation was associated with a higher IKDC score.

Conclusions

This 22-year follow-up study of PT, with objective outcome parameters next to patient-reported outcome measurements in a unique group of patients, shows that overall 66% was without major revision surgery and patient characteristics also influence long-term outcome of cartilage repair surgery.

中文翻译：

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软骨膜移植软骨修复手术二十二年的结果。

客观的

本研究的主要目的是评估软骨膜移植（PT）术后至少 22 年进行重大翻修手术的风险，并评估患者特征的影响。

设计

主要结局是治疗成功或失败。PT 失败被定义为移除移植物的翻修手术，例如（单髁）膝关节置换术或髌骨切除术。使用国际膝关节文献委员会 (IKDC) 评分对未失败患者的功能进行评估。此外，还评估了患者特征的影响。

结果

88 名年龄在 16 至 55 岁之间、有症状的软骨缺损患者的 90 个膝关节接受了 PT 治疗。78 名患者的 80 个膝盖符合分析条件，10 名患者失访。26 名患者的 28 个膝盖接受了重大修复手术。既往手术和 PT 前较长时间的症状与软骨修复失败的风险增加显着相关。使用 IKDC 评分分析其余 52 名患者的功能和患者特征的影响。他们的 IKDC 评分中位数为 39.08，但移植时相对年轻的年龄与较高的 IKDC 评分相关。

结论

这项为期 22 年的 PT 随访研究，在一组独特的患者中使用客观结果参数以及患者报告的结果测量结果显示，总体上 66% 的患者没有进行重大翻修手术，并且患者特征也影响软骨的长期结果修复手术。