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Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
Oxidative Medicine and Cellular Longevity Pub Date : 2020-09-15 , DOI: 10.1155/2020/5245308
Chainika Khatana 1, 2 , Neeraj K. Saini 3, 4 , Sasanka Chakrabarti 5 , Vipin Saini 6 , Anil Sharma 1 , Reena V. Saini 1 , Adesh K. Saini 1
Affiliation  

Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of cardiovascular events contributing to the most considerable number of morbidity and mortality worldwide. Factors like cellular senescence, genetics, clonal haematopoiesis, sedentary lifestyle-induced obesity, or diabetes mellitus upsurge the tendency of atherosclerosis and are foremost pioneers to definitive transience. Accumulation of oxidized low-density lipoproteins (Ox-LDLs) in the tunica intima triggers the onset of this disease. In the later period of progression, the build-up plaques rupture ensuing thrombosis (completely blocking the blood flow), causing myocardial infarction, stroke, and heart attack, all of which are common atherosclerotic cardiovascular events today. The underlying mechanism is very well elucidated in literature but the therapeutic measures remains to be unleashed. Researchers tussle to demonstrate a clear understanding of treating mechanisms. A century of research suggests that lowering LDL, statin-mediated treatment, HDL, and lipid-profile management should be of prime interest to retard atherosclerosis-induced deaths. We shall brief the Ox-LDL-induced atherogenic mechanism and the treating measures in line to impede the development and progression of atherosclerosis.

中文翻译:

氧化的低密度脂蛋白诱导的动脉粥样硬化的机械性见解。

血脂异常在臭名昭著的动脉粥样硬化(一种中型至大型动脉疾病)的发作中具有重要作用。动脉粥样硬化是心血管事件的主要根源,是导致全世界最大量的发病和死亡的原因。诸如细胞衰老,遗传,克隆性造血,久坐不动的生活方式引起的肥胖或糖尿病等因素使动脉粥样硬化的趋势高涨,并且是最终确定性的先驱。内膜内膜中氧化的低密度脂蛋白(Ox-LDLs)的积累触发了该病的发作。在进展的后期,堆积的斑块破裂,继而形成血栓(完全阻塞血流),引起心肌梗塞,中风和心脏病发作,所有这些都是当今常见的动脉粥样硬化性心血管事件。文献中已经很好地阐明了其潜在机制,但是治疗措施仍有待开发。研究人员争吵表明对治疗机制有清晰的认识。一项世纪的研究表明,降低LDL,他汀类药物介导的治疗,HDL和脂质分布管理对延缓由动脉粥样硬化引起的死亡具有重要意义。我们将简要介绍Ox-LDL致动脉粥样硬化的机制和治疗措施,以阻止动脉粥样硬化的发生和发展。脂质分布管理对于延缓动脉粥样硬化引起的死亡至关重要。我们将简要介绍Ox-LDL诱导的动脉粥样硬化的发生机理和治疗措施,以阻止动脉粥样硬化的发生和发展。脂质分布管理对于减少动脉粥样硬化引起的死亡至关重要。我们将简要介绍Ox-LDL诱导的动脉粥样硬化的发生机理和治疗措施,以阻止动脉粥样硬化的发生和发展。
更新日期:2020-09-15
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