Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.

中文翻译：

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两种带有吡啶并噻唑衍生物的锌（II）配合物的合成，晶体结构以及抗菌和抗肿瘤研究

两种吡啶噻唑衍生物，即4-（吡啶-2-基）-2-（2-（吡啶-2-基亚甲基）肼基）噻唑（L1）和4-（吡啶-3-基）-2-（2 -（吡啶-4-基亚甲基）肼基）噻唑（L2）通过α之间的环化反应获得分别通过配体与相应的金属盐反应制备了卤代酮和硫代酰胺，以及它们的Zn（II）配合物，并通过X射线衍射和元素分析对其进行了表征。两种晶体均通过醚扩散获得，并在单斜晶系统中结晶。使用酶标仪对Zn（II）配合物和配体的体外抗菌活性进行了筛选，并通过MTT对配合物的体外抗肿瘤活性进行了评估，以期开发出具有新特性的改良生物活性材料。化合物的生物学活性研究表明，金属配合物比游离配体更具活性，并且某些化合物对某些细菌或癌细胞系具有绝对特异性。