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Targeting lipid metabolism in liver cancer.
Biochemistry ( IF 2.9 ) Pub Date : 2020-09-15 , DOI: 10.1021/acs.biochem.0c00477 Malak Alannan 1, 2 , Hussein Fayyad-Kazan 3 , Véronique Trézéguet 1 , Aksam Merched 1
Biochemistry ( IF 2.9 ) Pub Date : 2020-09-15 , DOI: 10.1021/acs.biochem.0c00477 Malak Alannan 1, 2 , Hussein Fayyad-Kazan 3 , Véronique Trézéguet 1 , Aksam Merched 1
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Cancer cells are highly dependent on different metabolic pathways for sustaining their survival, growth, and proliferation. Lipid metabolism not only provides the energetic needs of the cells but also provides the raw material for cellular growth and the signaling molecules for many oncogenic pathways. Mainly processed in the liver, lipids play an essential role in the physiology of this organ and in the pathological progression of many diseases such as metabolic syndrome and hepatocellular carcinoma (HCC). The progression of HCC is associated with inflammation and complex metabolic reprogramming, and its prognosis remains poor because of the lack of effective therapies despite many years of dedicated research. Defects in hepatic lipid metabolism induce abnormal gene expression and rewire many cellular pathways involved in oncogenesis and metastasis, implying that interfering with lipid metabolism within the tumor and the surrounding microenvironment may be a novel therapeutic approach for treating liver cancer patients. Therefore, this review focuses on the latest advances in drugs targeting lipid metabolism and leading to promising outcomes in preclinical studies and some ongoing clinical trials.
中文翻译：
靶向脂质代谢在肝癌中。
癌细胞高度依赖于不同的代谢途径来维持其生存，生长和增殖。脂质代谢不仅提供了细胞的能量需求，还提供了细胞生长的原材料和许多致癌途径的信号分子。脂质主要在肝脏中加工，在该器官的生理以及许多疾病（例如代谢综合征和肝细胞癌（HCC））的病理进展中起着至关重要的作用。HCC的进展与炎症和复杂的代谢重编程有关，尽管多年的专门研究，但由于缺乏有效的疗法，其预后仍然很差。肝脂质代谢中的缺陷会诱导异常的基因表达，并使许多参与肿瘤发生和转移的细胞途径重新发生变化，这意味着干扰肿瘤和周围微环境中的脂质代谢可能是治疗肝癌患者的一种新颖的治疗方法。因此，本综述着重于针对脂质代谢的药物的最新进展，并在临床前研究和一些正在进行的临床试验中带来了可喜的结果。
更新日期：2020-10-21
中文翻译：
靶向脂质代谢在肝癌中。
癌细胞高度依赖于不同的代谢途径来维持其生存，生长和增殖。脂质代谢不仅提供了细胞的能量需求，还提供了细胞生长的原材料和许多致癌途径的信号分子。脂质主要在肝脏中加工，在该器官的生理以及许多疾病（例如代谢综合征和肝细胞癌（HCC））的病理进展中起着至关重要的作用。HCC的进展与炎症和复杂的代谢重编程有关，尽管多年的专门研究，但由于缺乏有效的疗法，其预后仍然很差。肝脂质代谢中的缺陷会诱导异常的基因表达，并使许多参与肿瘤发生和转移的细胞途径重新发生变化，这意味着干扰肿瘤和周围微环境中的脂质代谢可能是治疗肝癌患者的一种新颖的治疗方法。因此，本综述着重于针对脂质代谢的药物的最新进展，并在临床前研究和一些正在进行的临床试验中带来了可喜的结果。
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