RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a series of cell physiological activities. In this review, we discuss the structure of RCC1 and describe how RCC1 affects the formation and function of the nuclear envelope, spindle formation, and nuclear transport. We mainly focus on the effect of RCC1 on the cell cycle during tumorigenesis and the recent research progress that has been made in relation to different tumor types.

中文翻译：

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RCC1在肿瘤发生中的多重作用

RCC1（染色体浓缩1的调节子）是Ran（一种核Ras样G蛋白）唯一已知的鸟嘌呤核苷酸交换因子。RCC1与染色质和Ran结合以建立RanGTP的浓度梯度，从而参与一系列细胞生理活动。在这篇综述中，我们讨论了RCC1的结构，并描述了RCC1如何影响核包膜的形成和功能，纺锤体形成以及核运输。我们主要关注RCC1对肿瘤发生过程中细胞周期的影响，以及有关不同肿瘤类型的最新研究进展。