Frontiers in Cellular Neuroscience ( IF 4.2 ) Pub Date : 2020-08-24 , DOI: 10.3389/fncel.2020.524791 Bradly Alicea 1, 2
The differentiation of neurons and formation of connections between cells is the basis of both the adult phenotype and behaviors tied to cognition, perception, reproduction, and survival. Such behaviors are associated with local (circuits) and global (connectome) brain networks. A solid understanding of how these networks emerge is critical. This opinion piece features a guided tour of early developmental events in the emerging connectome, which is crucial to a new view on the connectogenetic process. Connectogenesis includes associating cell identities with broader functional and developmental relationships. During this process, the transition from developmental cells to terminally differentiated cells is defined by an accumulation of traits that ultimately results in neuronal-driven behavior. The well-characterized developmental and cell biology of
中文翻译:
提高连接组:秀丽隐杆线虫神经元活动和行为的出现
神经元的分化和细胞之间连接的形成是与认知、感知、繁殖和生存相关的成体表型和行为的基础。这些行为与局部(电路)和全局(连接组)大脑网络有关。深入了解这些网络是如何出现的至关重要。这篇评论文章对新兴连接组的早期发育事件进行了引导,这对于对连接发生过程的新观点至关重要。连接发生包括将细胞身份与更广泛的功能和发育关系联系起来。在此过程中,从发育细胞到终末分化细胞的转变是由最终导致神经元驱动行为的特征积累所定义的。充分表征的发育和细胞生物学