Bisphosphonates are often used to treat osteoporosis, malignant bone metastases, and hypercalcemia. However, it can cause serious adverse reactions, bisphosphonate-related osteonecrosis of the jaw (BRONJ), which seriously affects the quality of life of patients. At present, the treatment of BRONJ is still difficult to reach an agreement, and there is no effective treatment. Therefore, it is very important to find effective treatments. Many studies have shown that the occurrence of BRONJ may be due to unbalanced bone turnover, anti-angiogenesis, bacterial infection, direct tissue toxicity, and abnormal immune function. The previous research results show that tetrahedral framework nucleic acids (tFNAs), a new type of nanomaterial, can promote various biological activities of cells, such as cell proliferation, migration, anti-inflammation and anti-oxidation, and angiogenesis. Therefore, we intend to explore the potential of tFNAs in the treatment of BRONJ through this study. The results show that tFNAs can promote the treatment of BRONJ by promoting angiogenesis and promoting M2 polarization in macrophages and inhibiting M1 polarization both in vitro and in vivo. These results provide a theoretical basis for the application of tFNAs in the treatment of BRONJ and also provide new ideas and methods for the treatment of other diseases based on ischemia and immune disorders.

中文翻译：

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四面体框架核酸通过促进血管生成和M2极化，促进与双膦酸盐有关的颌骨坏死的治疗。

双膦酸盐通常用于治疗骨质疏松，恶性骨转移和高钙血症。但是，它可能导致严重的不良反应，即双膦酸盐相关的颌骨坏死（BRONJ），严重影响患者的生活质量。目前，BRONJ的治疗仍难以达成共识，尚无有效的治疗方法。因此，找到有效的治疗方法非常重要。许多研究表明，BRONJ的发生可能是由于骨代谢不平衡，抗血管生成，细菌感染，直接组织毒性和异常的免疫功能引起的。先前的研究结果表明，四面体框架核酸（tFNA）是一种新型的纳米材料，可以促进细胞的各种生物活性，例如细胞增殖，迁移，抗发炎，抗氧化和血管生成。因此，我们打算通过这项研究探索tFNAs在治疗BRONJ中的潜力。结果表明，tFNAs可以通过促进血管生成和促进巨噬细胞中的M2极化并在体内和体外抑制M1极化来促进BRONJ的治疗。这些结果为tFNAs在治疗BRONJ中的应用提供了理论基础，也为基于缺血和免疫疾病的其他疾病的治疗提供了新的思路和方法。结果表明，tFNAs可以通过促进血管生成和促进巨噬细胞中的M2极化并在体内和体外抑制M1极化来促进BRONJ的治疗。这些结果为tFNAs在治疗BRONJ中的应用提供了理论基础，也为基于缺血和免疫疾病的其他疾病的治疗提供了新的思路和方法。结果表明，tFNAs可以通过促进血管生成和促进巨噬细胞中的M2极化并在体内和体外抑制M1极化来促进BRONJ的治疗。这些结果为tFNAs在治疗BRONJ中的应用提供了理论基础，也为基于缺血和免疫疾病的其他疾病的治疗提供了新的思路和方法。