High-Strength and High-Toughness Silk Fibroin Hydrogels: A Strategy Using Dynamic Host–Guest Interactions,ACS Applied Bio Materials

当前位置： X-MOL 学术 › ACS Appl. Bio Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

High-Strength and High-Toughness Silk Fibroin Hydrogels: A Strategy Using Dynamic Host–Guest Interactions
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-09-14 , DOI: 10.1021/acsabm.0c00933
Xiaowei Huang ₁ , Mengya Zhang ₂ , Jinfa Ming ₁ , Xin Ning ₁ , Shumeng Bai ₂

Affiliation

Natural polymer-based hydrogels attract great attention because of their inherent biocompatibility and controllable biodegradability. However, the broad applications of these hydrogels require a combination of high mechanical strength, high toughness, fatigue resistance, as well as self-healing. The integration of this combination into one natural polymer-based hydrogel remains challenging. Here, a molecular design strategy was proposed to fabricate mechanically robust silk fibroin-based hydrogels using host–guest interactions. Silk fibroin molecules was chemically modified with cholesterol (Chol, guest) or β-cyclodextrin (β-CD, host), and host–guest interaction between Chol and β-CD moieties drove the supramolecular assemblies of hydrogels. The dissociation/reassociation behavior of host–guest complexation, serving as sacrificial bonds, endowed hydrogels with effective energy dissipation and rapid self-healing ability. The prepared silk fibroin-based hydrogels exhibited high mechanical strength, high toughness, and remarkable fatigue resistance, superior to conventional silk fibroin hydrogels. Moreover, due to reversible host–guest interactions, hydrogels achieved facile functional recovery after damage without any external stimuli. This design strategy provides an avenue to develop natural polymer-based materials with robust mechanical properties, thus broadening current hydrogel applications.

中文翻译：

高强度和高韧性丝素蛋白水凝胶：使用动态主客相互作用的策略

天然聚合物基水凝胶因其固有的生物相容性和可控的生物降解性而备受关注。然而，这些水凝胶的广泛应用需要结合高机械强度、高韧性、抗疲劳性以及自愈性。将这种组合整合到一种基于天然聚合物的水凝胶中仍然具有挑战性。在这里，提出了一种分子设计策略，以利用主客体相互作用制造机械坚固的基于丝素蛋白的水凝胶。丝素蛋白分子用胆固醇（Chol，客体）或 β-环糊精（β-CD，宿主）进行化学修饰，Chol 和 β-CD 部分之间的主客体相互作用驱动了水凝胶的超分子组装。主客体络合的解离/重新结合行为，作为牺牲键，赋予水凝胶有效的能量耗散和快速的自愈能力。制备的基于丝素蛋白的水凝胶表现出高机械强度、高韧性和显着的抗疲劳性，优于传统的丝素蛋白水凝胶。此外，由于可逆的主客体相互作用，水凝胶在损伤后无需任何外部刺激即可轻松恢复功能。这种设计策略为开发具有强大机械性能的天然聚合物基材料提供了一条途径，从而拓宽了当前的水凝胶应用。由于可逆的主客体相互作用，水凝胶在损伤后无需任何外部刺激即可轻松恢复功能。这种设计策略为开发具有强大机械性能的天然聚合物基材料提供了一条途径，从而拓宽了当前的水凝胶应用。由于可逆的主客体相互作用，水凝胶在损伤后无需任何外部刺激即可轻松恢复功能。这种设计策略为开发具有强大机械性能的天然聚合物基材料提供了一条途径，从而拓宽了当前的水凝胶应用。

更新日期：2020-10-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11