ABSTRACT

Background

Alzheimer’s disease (AD) is the most common form of dementia. Its neurodegenerative nature and the lack of a curative treatment result in a substantial burden for healthcare systems and society. This study aimed to analyze the hospital incidence and mortality of AD in Spain and to evaluate patients’ use of healthcare resources and direct medical costs.

Methods

Admission records of patients with AD treated in hospitals in Spain between 2011 and 2016 were selected from a Spanish hospital discharge database.

Results

Records of 7,894 patients with diagnosed AD were analyzed. Hospital incidence was 3.7 per 10,000 persons over the study period, 2.9 and 4.4 for males and females, respectively. In-hospital mortality was 9.5%; both hospital incidence and in-hospital mortality increased over the study period. Mortality was principally associated with acute respiratory failure and other diseases of the respiratory system and heart failure. Annual medical costs of specialized care increased slightly during the study period, with a mean annual cost per patient of €4,969.

Conclusions

AD is responsible for an increasing proportion of hospitalizations in Spain and raising medical costs, which highlights the importance of early detection and optimized care.

中文翻译：

---

西班牙阿尔茨海默病的医院发病率、死亡率和费用：一项回顾性多中心研究

摘要

背景

阿尔茨海默病 (AD) 是最常见的痴呆症。它的神经退行性性质和缺乏治愈性治疗给医疗保健系统和社会带来了沉重的负担。本研究旨在分析西班牙 AD 的医院发病率和死亡率，并评估患者对医疗资源的使用和直接医疗费用。

方法

2011 年至 2016 年期间在西班牙医院接受治疗的 AD 患者的入院记录选自西班牙出院数据库。

结果

分析了 7,894 名诊断为 AD 的患者的记录。在研究期间，医院发病率为每 10,000 人 3.7 人，男性和女性分别为 2.9 和 4.4。住院死亡率为 9.5%；在研究期间，住院发病率和住院死亡率均有所增加。死亡率主要与急性​​呼吸衰竭和其他呼吸系统疾病和心力衰竭有关。在研究期间，专业护理的年度医疗费用略有增加，每位患者的平均年费用为 4,969 欧元。

结论

AD 是造成西班牙住院人数增加和医疗费用增加的原因，这凸显了早期发现和优化护理的重要性。