Abstract Naoxintong Capsule (NXT), a Chinese medicine, has been widely used for the treatment of cardiovascular diseases in clinic. The present study was designed to clarify the effects of NXT on haemorheology, blood coagulation, hepatic function, antioxidant capacity and inflammatory responses in a rat model of blood stasis syndrome. Rats were placed in ice-cold water for 5 min during the time interval of two adrenaline injections to induce blood circulation disorders after intragastric administration of 10 consecutive days. Blood was collected from abdominal aorta to determine whole blood viscosity (WBV), plasma viscosity (PV), activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), malonaldehyde (MDA), alanine transaminase (ALT), aspartate transaminase (AST), interleukin-1β (IL-1β), interleukin-6 (IL-6), platelet activating factor (PAF). The results showed that NXT could significantly decrease the WBV, PV, FIB and prolong the APTT and PT. Meanwhile, NXT significantly decreased the serum contents of MDA, IL-1β, IL-6, ALT, AST and PAF, while elevating T-AOC and SOD levels. These results indicate that NXT could improve coagulation function, enhance antioxidant capacity and suppress inflammation, which might partly account for its mechanisms of action in preventing and treating cardiovascular diseases.

中文翻译：

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脑心通胶囊对血瘀证大鼠的保护作用

摘要 脑心通胶囊（NXT）是一种中药，在临床上广泛用于治疗心血管疾病。本研究旨在阐明 NXT 对血瘀证大鼠模型血液流变学、凝血、肝功能、抗氧化能力和炎症反应的影响。连续灌胃10天后，在两次肾上腺素注射的时间间隔内，将大鼠置于冰冷的水中5分钟，以诱发血液循环障碍。腹主动脉采血测定全血粘度（WBV）、血浆粘度（PV）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、纤维蛋白原（FIB）、总抗氧化能力（T-AOC）、超氧化物歧化酶 (SOD)、丙二醛 (MDA)、丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)、白介素-1β (IL-1β)、白介素-6 (IL-6)、血小板活化因子 (PAF)。结果表明，NXT可显着降低WBV、PV、FIB，延长APTT和PT。同时，NXT显着降低血清MDA、IL-1β、IL-6、ALT、AST和PAF的含量，同时升高T-AOC和SOD水平。这些结果表明NXT可以改善凝血功能、增强抗氧化能力和抑制炎症，这可能部分解释了其预防和治疗心血管疾病的作用机制。AST 和 PAF，同时提高 T-AOC 和 SOD 水平。这些结果表明NXT可以改善凝血功能、增强抗氧化能力和抑制炎症，这可能部分解释了其在预防和治疗心血管疾病方面的作用机制。AST 和 PAF，同时提高 T-AOC 和 SOD 水平。这些结果表明NXT可以改善凝血功能、增强抗氧化能力和抑制炎症，这可能部分解释了其预防和治疗心血管疾病的作用机制。