Abstract In this present study, different forms of quercetin encapsulated beads were synthesized, namely ionic cross-linked gel beads and cryogel beads. Fourier Transform Infrared (FT-IR) spectra of the beads were used to characterize and prove quercetin encapsulation in alginate beads. Swelling and drying profiles were studied. Besides, release kinetics of quercetin molecules from gel beads and cryogels were carefully investigated in two different solvent/media; dimethyl sulfoxide (DMSO) and Roswell Park Memorial Institute Medium (RPMI-1640). Based upon the release kinetic studies, it is found that quercetin release from alginate cryogel beads fits the first-order release model in DMSO and it depends on the concentration of quercetin in the beads. The release of quercetin from alginate gel beads was described by the Higuchi release model, which highlights the release of quercetin molecules through the pores of the matrix. In RPMI-1640, the release of quercetin from both forms of alginate beads fits zero-order release model and it indicates a constant release of quercetin per unit time. Finally, the radical scavenging activity of the quercetin quantities was tested by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test, and successful results were obtained compared to reference material. Graphical Abstract

中文翻译：

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槲皮素包裹海藻酸盐珠的合成及其抗氧化和释放动力学研究

摘要 在本研究中，合成了不同形式的槲皮素包封珠粒，即离子交联凝胶珠粒和冷冻凝胶珠粒。珠子的傅立叶变换红外 (FT-IR) 光谱用于表征和证明藻酸盐珠子中的槲皮素包封。研究了溶胀和干燥曲线。此外，在两种不同的溶剂/介质中仔细研究了槲皮素分子从凝胶珠和冷冻凝胶中的释放动力学；二甲基亚砜 (DMSO) 和罗斯威尔公园纪念研究所培养基 (RPMI-1640)。根据释放动力学研究，发现藻酸盐冷冻凝胶珠中槲皮素的释放符合 DMSO 中的一级释放模型，它取决于珠中槲皮素的浓度。Higuchi 释放模型描述了槲皮素从藻酸盐凝胶珠中的释放，这突出了槲皮素分子通过基质孔的释放。在 RPMI-1640 中，两种形式的藻酸盐珠中槲皮素的释放均符合零级释放模型，表明每单位时间槲皮素的释放量恒定。最后，通过 2,2-diphenyl-1-picrylhydrazyl (DPPH) 试验测试了槲皮素量的自由基清除活性，与参考材料相比获得了成功的结果。图形概要 并且与参考材料相比获得了成功的结果。图形概要 并且与参考材料相比获得了成功的结果。图形概要