ABSTRACT Emerging clinical studies suggest that flaxseed oil may be an effective intervention for the management of depression. The current trial was conducted to assess the effect of flaxseed oil supplementation on the Brain-derived neurotrophic factor (BDNF), and the psychological status of women with depression. Subjects of 60 depressed women aged 18–45 were randomly divided into two groups. One group was asked to consume a 1000 mg flaxseed oil capsule, twice a day for 10 weeks, while the other consumed a placebo. Serum (BDNF), Beck Depression Inventory-II (BDI-II) questionnaire, and anthropometric indices were measured before and after intervention. This study showed that serum BDNF concentration in the supplementation group increased significantly after 10-week intervention, compared with placebo (1.12 ± 0.6 pg/ml vs. 0.2 ± 0.56 pg/ml; p < .0001). Total BDI-II score was significantly lower after flaxseed oil supplementation, compared with placebo (−16.62 ± 7.03, −8.45 ± 7.8; p < .0001). The present study showed that flaxseed oil supplementation can confer a number of health benefits in depressed women, including increased serum BDNF concentrations, along with improvements in depression status.

中文翻译：

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亚麻籽油补充剂对抑郁症严重程度和脑源性神经营养因子的影响：一项随机、双盲、安慰剂对照的临床试验

摘要 新兴的临床研究表明，亚麻籽油可能是治疗抑郁症的有效干预措施。目前的试验是为了评估亚麻籽油补充剂对脑源性神经营养因子 (BDNF) 的影响，以及抑郁症女性的心理状态。将 60 名 18-45 岁的抑郁女性受试者随机分为两组。一组被要求服用 1000 毫克亚麻籽油胶囊，每天两次，持续 10 周，而另一组服用安慰剂。在干预前后测量血清（BDNF）、贝克抑郁量表-II（BDI-II）问卷和人体测量指标。该研究表明，与安慰剂相比，补充组的血清 BDNF 浓度在 10 周干预后显着增加（1.12 ± 0.6 pg/ml vs. 0.2 ± 0.56 pg/ml；p < .0001）。与安慰剂相比，补充亚麻籽油后 BDI-II 总分显着降低（-16.62 ± 7.03，-8.45 ± 7.8；p < .0001）。目前的研究表明，亚麻籽油补充剂可以为抑郁女性带来许多健康益处，包括增加血清 BDNF 浓度，以及改善抑郁状态。